Xenobiotics in Chemical Carcinogenesis
Title | Xenobiotics in Chemical Carcinogenesis PDF eBook |
Author | Akhileshwar Kumar Srivastava |
Publisher | Academic Press |
Pages | 328 |
Release | 2022-02-17 |
Genre | Science |
ISBN | 0323906818 |
Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants. Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans
Xenobiotics and Cancer
Title | Xenobiotics and Cancer PDF eBook |
Author | Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium |
Publisher | Taylor & Francis |
Pages | 394 |
Release | 1991 |
Genre | Biotransformation (Metabolism) |
ISBN | 9780748400379 |
The 21st International Symposium of the Princess Takamatsu Cancer Resarch Fund covered advances in chemical carcinogenesis and cancer chemotherapy. It notes that humans are continuously exposed to carcinogens, so the amount of carcinogenic xenobiotics and the human response to them is important.
Xenobiotics and Cancer; Implications for Chemical Carcinogenesis and Cancer Chemotherapy
Title | Xenobiotics and Cancer; Implications for Chemical Carcinogenesis and Cancer Chemotherapy PDF eBook |
Author | Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium |
Publisher | |
Pages | 368 |
Release | 1991 |
Genre | Cancer |
ISBN | 9784762246678 |
Chemical Carcinogenesis
Title | Chemical Carcinogenesis PDF eBook |
Author | Università degli studi di Sassari |
Publisher | |
Pages | |
Release | |
Genre | |
ISBN |
Chemical Carcinogenesis
Title | Chemical Carcinogenesis PDF eBook |
Author | Università degli studi di Sassari |
Publisher | |
Pages | 195 |
Release | 1984 |
Genre | |
ISBN |
Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds
Title | Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds PDF eBook |
Author | |
Publisher | Academic Press |
Pages | 538 |
Release | 1994-07-06 |
Genre | Science |
ISBN | 0080581188 |
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics. This special volume of Advances in Pharmacology features a two-color dust jacket. Summarizes the most recent information on: Xenobiotic conjugation Drug toxicity, hypersensitivity, and targeting Chemical carcinogenesis Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity Bioactivation and bioconversion
Molecular Aspects of Oxidative Drug Metabolizing Enzymes
Title | Molecular Aspects of Oxidative Drug Metabolizing Enzymes PDF eBook |
Author | Emel Arinc |
Publisher | Springer Science & Business Media |
Pages | 615 |
Release | 2013-06-29 |
Genre | Science |
ISBN | 3642795285 |
Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.