Ladies and Gentlemen: An earnest espousal of the Anti-Slavery cause for a quarter of a century, under circumstances which have served in a special manner to identify my name and labours with it, will shield me from the charge of egotism, in assuming to be its exponent—at least for myself—on this occasion. All that I can compress within the limits of a single lecture, by way of its elucidation, it shall be my aim to accomplish. I will make a clean breast of it. You shall know all that is in my heart pertaining to Slavery, its supporters, and apologists.

Though plagued by illness and death in his family in the years covered here, Garrison strove to win supporters for abolitionism, lecturing and touring with Frederick Douglass. He continued to write for The Liberator and involved himself in many liberal causes; in 1849 he publicized and circulated the earliest petition for women's suffrage.