Description: ALS William Clark, St. Louis, to Meriwether Lewis Clark. Describes a duel at Jefferson Barracks between Lt. May and Mr. Hamilton. William also offers news of Meriwether's siblings.

Description: ALS Harriet Kennerly Radford Clark and William Clark to Meriwether Lewis Clark. Describes activities at Jefferson Barracks and in the city of St. Louis, including the names of people who are building homes in the city. Also mentions a duel between Capt. Harrison and Dr. Randolph on the “Island.” (Probably “Bloody Island,” located in the Mississippi River near St. Louis.).

Description: ALS William Clark, St. Louis, to Meriwether Lewis Clark. “Troops it appears are moving in every direction.”.

Description: ALS William Clark, Washington City, to Meriwether Lewis Clark. Mentions three regiments of men to be stationed at Bellefontaine and an arsenal near St. Louis. Asks him to write to the family as often as possible.

Description: ALS William Clark, St. Louis, to Meriwether Lewis Clark. Mentions two women taken prisoner by the Sacs and returned by the Winnebago. Two other prisoners seem to have been killed. "60 kickapoo's of Oswago River have just arrived". William Preston Clark is also noted to have expressed interest in "going to the army".

Description: ALS William Clark, St. Louis, to Meriwether Lewis Clark. Notifies his son that the Indians have relinquished their claim on c certain lands "to make room for other tribes". He also remarks on how much Meriwether is missed by the family: "The anxieties of the family about you is greater than I could have supposed any large family could have shown in the separation of one of it's members".

Description: ALS William Clark, St. Louis, to Meriwether Lewis Clark. Also remarks on eagerness to discuss Meriwether's future career plans on their next meeting, urging him not to "leave the army before you have another course of pursuit, as a young man without employment". Social weddings and meetings also feature.