"Here, my previous edition of Viruses, Plagues, & History is updated to reflect both progress and disappointment since that publication. This edition describes newcomers to the range of human infections, specifically, plagues that play important roles in this 21st century. The first is Middle East Respiratory Syndrome (MERS), an infection related to Sudden Acute Respiratory Syndrome (SARS). SARS was the first new-found plague of this century. Zika virus, which is similar to yellow fever virus in being transmitted by mosquitos, is another of the recent scourges. Zika appearing for the first time in the Americas is associated with birth defects and a paralytic condition in adults. Lastly, illness due to hepatitis viruses were observed prominently during the second World War initially associated with blood transfusions and vaccine inoculations. Since then, hepatitis virus infections have afflicted millions of individuals, in some leading to an acute fulminating liver disease or more often to a life-long persistent infection. A subset of those infected has developed liver cancer. However, in a triumph of medical treatments for infectious diseases, pharmaceuticals have been developed whose use virtually eliminates such maladies. For example, Hepatitis C virus infection has been eliminated from almost all (>97%) of its victims. This incredible result was the by-product of basic research in virology as well as cell and molecular biology during which intelligent drugs were designed to block events in the hepatitis virus life-cycle"--

More people were killed by smallpox during the twentieth century--over 300 million--than by all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 million lives. A century later, influenza is poised to return, ongoing plagues of HIV/AIDS and hepatitis infect millions, and Ebola, Zika, and West Nile viruses cause new concern and panic. The overlapping histories of humans and viruses are ancient. Earliest cities became both the cradle of civilization and breeding grounds for the first viral epidemics. This overlap is the focus of virologist/immunologist Michael Oldstone in Viruses, Plagues and History. Oldstone explains principles of viruses and epidemics while recounting stories of viruses and their impact on human history. This fully updated second edition includes engrossing new chapters on hepatitis, Zika, and contemporary threats such as the possible return of a catastrophic influenza, and the impact of fear of autism on vaccination efforts. This is a fascinating panorama of humankind's longstanding conflict with unseen viral enemies, both human successes--such as control of poliomyelitis, measles, smallpox and yellow fever, and continued dangers--such as HIV and Ebola. Impeccably researched and accessibly written, Viruses, Plagues and History will fascinate all with an interest in how viral illnesses alter the course of human history.

Oldstone presents a vivid history of a fascinating field, focusing on the most famous viruses humanity has battled: smallpox, polio, measles, yellow fever, and the new, unconquered strains of Ebola, Hantavirus, mad cow disease, and AIDS. 56 illustrations.

Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.

This book examines the early teachings of Buddhism associated with the life of the Buddha, Siddhatta Gotama. In these teachings, the Buddha put forward his famous Four Noble Truths concerning the nature of suffering, its causes, the Truth that it can be overcome, and a pathway to end suffering. The suffering experienced in the contemporary coronavirus pandemic may seem to be very distant from the Buddhas message delivered over two thousand years ago, but the teaching of the Four Noble Truths is as relevant today as it was all that time ago. So this book melds the two, occasionally with discrete treatment of past and present but ever cognizant of the ways in which the teachings of the past inform the present crisis. To understand coronaviruses, the book examines the nature of viruses, their origins, causes and the ways in which they are both friends and enemies of humankind. Importantly and crucially, the book investigates how far humanity itself is the cause of its own suffering in the pandemics that arise no less in the coronaviruses that have emerged in the twenty-first century. Chapters include: The Buddha; Viruses: Friends and Enemies; The Noble Truth of Suffering; The Second Noble Truth of the Cause of Suffering; The Third Noble Truth of the Cessation of Suffering; The Fourth Noble Truth: The Noble Eightfold Path; The Noble Eightfold Path: Mindfulness and Concentration; The Brahma-vihara: Love: Compassion: Sympathetic Joy: Equanimity.

From the bubonic plague to theoretical pathogens on other worlds, a sweeping look at the past, present, and future of mass infections—and how we battle them. In this panoramic and up-to-date account, we learn how the Black Death, smallpox, the 1918 influenza pandemic, and other great epidemics have not only led to enormous suffering and mass death but have also contributed to the fall of empires and changed the course of history. We also discover how new infectious diseases such as HIV/AIDS and COVID-19 emerge—and how we wage war against them. Humanity has struck back at the microbes: antibiotics and new vaccines have saved millions of lives. But the battle with these relentless, silent enemies is far from won. We face increasing threats from new and unavoidable pandemics, antibiotic resistance, and even potential extraterrestrial microbes. Duel Without End is a fascinating journey through the long history of infection, from the dawn of life to humanity’s future exploration of deep space.

The ideal text for undergraduate students majoring in biology, microbiology, medical technology, or pre-med, the Second Edition of Understanding Viruses provides a balanced approach to this fascinating discipline, combining the molecular, clinical, and historical aspects of virology. Updated throughout to keep pace with this fast-paced field, the text provides a strong, comprehensive introduction to human viral diseases. New material on molecular virology as well as new virus families presented coupled with chapters on viral diseases of animals; the history of clinical trials, gene therapy, and xenotranplantation; prions and viroids; plant viruses; and bacteriophages add to the scope of the text. Chapters discussing specific viral diseases weave in an epidemiological and global perspective and include treatment and prevention information. Contemporary case studies, Refresher Boxes, and Virus Files engage students in the learning process. With a wealth of student and instructor support tools, Understanding Viruses is an accessible, exciting, and engaging text for your virology course.