This work, naming 4,000 related individuals, contains the lineages of about fifty families, the main branches of which were located in Virginia, Maryland, and North and South Carolina. Genealogies of the following families are given: Allen, Aston, Barker-Bradford-Taylor, Berkeley-Ligon-Norwood, Binns, Butler, Claiborne, Clark, Colclough, Crafford, Crayfford-Crafford, Davis, Doniphan, Eldridge, Flood, Godwyn, Gray, Gregg, Griffis, Grigsby, Harris, Haynes, Jones, Mallory, Mason, Moore, Mumford-DeJarnette-Perryman, Newton, Norwood, Pace, Peche-Cornish-Everard-Mildmay-Harcourt-Crispe, Reade, Ruffin, Sledge, Smith, Sowerby-Sorsby, Stone-Smallwood-Smith, Stover, Thomas, Travis, Warren, Woodliffe, Wynne, and Wythe.

From Tyler's quarterly historical and genealogical magazine.

Wise's Eastern Shore of Virginia is a history of the counties of Accomack and Northampton; however, genealogists will be drawn to the book's numerous references to families prominent on the Eastern Shore and to the extensive lists of early settlers and patentees of land.