Chaperonins are a unique class of molecular chaperone that assist in the folding of newly synthesized, partially folded, and misfolded proteins. The importance of these folding machines is evident by their conservation across all three branches of life. The general structure of the chaperonins consists of 14-18 subunits, which form two back-to-back cavities. Unfolded polypeptide substrate is captured in one of the two cavities, and assisted to its native conformation in an ATP dependent fashion. The chaperonins can be separated into two, related, but unique groups. The group I chaperonins, typified by GroEL from bacteria, are fairly well understood, however, there are substantial gaps in our knowledge of the group II chaperonins, such as TRiC from the eukaryotic cytosol. Gaining a mechanistic understanding of the group II chaperonins is of great importance, as it has been shown that TRiC malfunction is associated with a variety of diseases. Toward this end the group II chaperonin conformation cycle, ATPase, and substrate folding mechanism have been investigated. This work elucidates key components of the folding cycle and greatly increases our understanding of these folding machines.

in Part I, Fred Zeglin gives you an in depth study of what it takes to build an accurate hunting rifle. Fred has been building custom hunting rifles for over thirty years. His clients come from all walks of life and have one thing in common; when they go hunting they don't want to worry about the accuracy of their rifle.In Part II, Gordy Gritters explains the extreme accuracy requirements of a quality benchrest rifle. Gordy has nearly thirty years invested in building precision rifles. He is a competitive shooter as well as a gunsmith. Builder of many high accuracy rifles used by customers across North America to set records and win various rifle competitions including the Varmint Hunter Jamboree, Coyote Hunting National Championship, 1000 yard matches, 600 yard matches, F-Class matches, BR-50, IR 50-50, 100 and 200 yard benchrest matches, sniper matches, NRA service rifle matches, as well as for varmint and big game hunting.

Pudding, the youngest of three Furkins, or elves, living in a barrel in the basement of a human named Noah, proves that a shy Furkin is capable of great deeds like the heroes of the past.

"The first major reference work to investigate the history and vast scope of beer, The Oxford Companion to Beer features more than 1,100 A-Z entries written by 166 of the world's most prominent beer experts"-- Provided by publisher.

The Camper Book will captivate all those who dream of waving good-bye to the rat race from the window of their own moveable home, be it a camper, RV, travel trailer, camper van, or tiny camper. Not just for placid retirees anymore, camper culture has sprung up among simplicity-seeking millennials, retro-loving "glampers," sports and movie stars, aging hippies, contract workers, "road-schoolers," and others. Award-winning journalist Dave Hoekstra hit the road in his own custom camper van, named Bluebird, to explore the history, culture, subcultures, and future of camper life. Traveling and talking his way through US campsites, RV parks, landmarks, and communities, Hoekstra draws out revealing stories from all walks of life—from Americans who are downsizing material goods while upsizing spiritual pursuits to RV enthusiasts such as Grammy-winning singer-songwriter John Prine and Chicago Cubs manager Joe Maddon. A modern-day Studs Terkel, Hoekstra provides a delightful mix of oral history, in-depth reporting, and practical information, while photographer Jon Sall's beautiful color photographs illuminate the unique people, places, and rigs that typify camper life.

When bodies were discovered hidden in barrels in 1999 in South Australia, Jeremy Pudney was one of the first journalists to cover the case that stunned the entire world. In this authoritative and darkly compelling book he pieces together the complete story of the Snowtown murders.