With the first coronary balloon angioplasty in 1977 came the challenge of the wound healing process of retenosis. Together these events spawned a new field of medicine, vascular brachytherapy, conceived to resolve this leading complication of vascular intervention. In the ensuing 20 year quest to cure restenosis, radiation vascular therapy appears to be the next logical step, but it still needs validation. Just two years after the first edition, this second edition of Vascular Brachytherapy fulfils the promise to provide updated information about the meteoric progress made from recent collaborative investigations within this field. Migrating from ideas and pre-clinical observation to clinical practice, this second edition contains 48 new or revised chapters contributed by well known medical experts from widely disparate fields of medicine. Scientists, cardiologists, radiation safety officers, regulators, engineers and technicians substantiate their observations with clinical and non-clinical data, basic radiation principles and issues from an economic, regulatory and safety perspective. Very little is known about the immediate patient risks, environmental concerns and long term pathobiological responses. For a field which is still in its honeymoon phase due to early technology success, this single volume will serve as a long-range educational tool and trace, giving the field of vascular brachytherapy the intense and continuous evaluation it deserves. For an audience of clinicians, scientists and researchers from all the represented medical disciplines, this book provides in depth information and exposure to subjects within these diverse areas of expertise.

Written by the foremost experts in the field, this volume is a comprehensive text and practical reference on contemporary brachytherapy. The book provides detailed, site-specific information on applications and techniques of brachytherapy in the head and neck, central nervous system, breast, thorax, gastrointestinal tract, and genitourinary tract, as well as on gynecologic brachytherapy, low dose rate and high dose rate sarcoma brachytherapy, vascular brachytherapy, and pediatric applications. The book thoroughly describes and compares the four major techniques used in brachytherapy—intracavity, interstitial, surface-dose or mold therapy, and transluminal. Chapters detail particular techniques that are appropriate in specific clinical situations.

Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.

Peripheral vascular disease is a common, disabling malady, and patients seeking treatment may turn to their cardiologist for advice and treatment. Conventional treatment has always been medical management and, inevitably, surgical bypass, even amputation. Stents have had a significantly high impact on endoluminal treatment outcomes by preventing injury to the lumen, reducing the potential for hyperplasia and restenosis, as well as the likelihood of plaque disruption and embolization. This second edition brings together a combination of all the current evidence-based information with personal experience and is presented by a team of distinguished operators. Short Contents

Peripheral vascular disease is a common and disabling malady, and patients seeking treatment may turn to their cardiologist, whom they are seeing for existing cardio-vascular disease, for advice and treatment. Conventional treatment has always been medical management and, inevitably, surgical bypass, even amputation. Because stents have had a significantly high impact on endoluminal treatment outcomes by preventing injury to the lumen, reducing the potential for hyperplasia and restenosis, as well as the likelihood of plaque disruption and embolization, the 20 or so available peripheral vascular stents must be considered an alternative to bypass surgery.

Historically, vascular disease has been treated by a combination of open surgical procedures and medical management. Since the first description of a percutaneous procedure to dilate diseased lower limb arteries, the treatment of vascular disease has changed. Endovascular Intervention for Vascular Disease: Principles and Practice offers a diverse a

This extensively revised third edition provides a practically applicable guide to the pathophysiology, assessment and management of vascular disorders encountered in vascular surgical practice. It features detailed information on the latest developments in the pathophysiology of conditions including atherosclerosis, multi-organ failure, limb compartment syndromes and Raynaud’s phenomenon in a clear easy to digest format. Disorders such as reperfusion injuries, vasculitides, and aortic dissection are covered. Furthermore, key topics in vascular and endovascular practice such as radiation biology and radiation safety are also detailed. Each chapter contains a set of learning objectives and key references, enabling the reader to quickly identify key points. Mechanisms of Vascular Disease: A Textbook for Vascular Specialists comprehensively covers a variety of common and unusual pathophysiologies encountered in vascular surgery, and is an ideal resource for both the trainee, and practicing clinical vascular surgeon seeking an up-to-date resource on the topic.