WILEY-INTERSCIENCE PAPERBACK SERIES The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. ". . .Variance Components is an excellent book. It is organized and well written, and provides many references to a variety of topics. I recommend it to anyone with interest in linear models." —Journal of the American Statistical Association "This book provides a broad coverage of methods for estimating variance components which appeal to students and research workers . . . The authors make an outstanding contribution to teaching and research in the field of variance component estimation." —Mathematical Reviews "The authors have done an excellent job in collecting materials on a broad range of topics. Readers will indeed gain from using this book . . . I must say that the authors have done a commendable job in their scholarly presentation." —Technometrics This book focuses on summarizing the variability of statistical data known as the analysis of variance table. Penned in a readable style, it provides an up-to-date treatment of research in the area. The book begins with the history of analysis of variance and continues with discussions of balanced data, analysis of variance for unbalanced data, predictions of random variables, hierarchical models and Bayesian estimation, binary and discrete data, and the dispersion mean model.

Variance Components Estimation deals with the evaluation of the variation between observable data or classes of data. This is an up-to-date, comprehensive work that is both theoretical and applied. Topics include ML and REML methods of estimation; Steepest-Acent, Newton-Raphson, scoring, and EM algorithms; MINQUE and MIVQUE, confidence intervals for variance components and their ratios; Bayesian approaches and hierarchical models; mixed models for longitudinal data; repeated measures and multivariate observations; as well as non-linear and generalized linear models with random effects.

Summarizes information scattered in the technical literature on a subject too new to be included in most textbooks, but which is of interest to statisticians, and those who use statistics in science and education, at an advanced undergraduate or higher level. Overviews recent research on constructin

The components of variance is a notion essential to statisticians and quantitative research scientists working in a variety of fields, including the biological, genetic, health, industrial, and psychological sciences. Co-authored by Sir David Cox, the pre-eminent statistician in the field, this book provides in-depth discussions that set forth the essential principles of the subject. It focuses on developing the models that form the basis for detailed analyses as well as on the statistical techniques themselves. The authors include a variety of examples from areas such as clinical trial design, plant and animal breeding, industrial design, and psychometrics.

Summarizes information scattered in the technical literature on a subject too new to be included in most textbooks, but which is of interest to statisticians, and those who use statistics in science and education, at an advanced undergraduate or higher level. Overviews recent research on constructin

Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.

Systematic treatment of the commonly employed crossed and nested classification models used in analysis of variance designs with a detailed and thorough discussion of certain random effects models not commonly found in texts at the introductory or intermediate level. It also includes numerical examples to analyze data from a wide variety of disciplines as well as any worked examples containing computer outputs from standard software packages such as SAS, SPSS, and BMDP for each numerical example.