During the last decades, the amount of available genetic data on populations has growndrastically. From one side, a refinement of chemical technologies have made possible theextraction of the human genome of individuals at an accessible cost. From the other side,consortia of institutions and laboratories around the world have permitted the collectionof data on a variety of individuals and population. This amount of data raised hope onour ability to understand the deepest mechanisms involved in the functioning of our cells.Notably, genetic epidemiology is a field that studies the relation between the geneticfeatures and the onset of a disease. Specific statistical methods have been necessary forthose analyses, especially due to the dimensions of available data: in genetics, informationis contained in a high number of variables compared to the number of observations.In this dissertation, two contributions are presented. The first project called PIGE (Pathway-Interaction Gene Environment) deals with gene-environment interaction assessments.The second one aims at developing variable selection methods for data which has groupstructures in both the variables and the observations.The document is divided into six chapters. The first chapter sets the background of this work,where both biological and mathematical notations and concepts are presented and gives ahistory of the motivation behind genetics and genetic epidemiology. The second chapterpresent an overview of the statistical methods currently in use for genetic epidemiology.The third chapter deals with the identification of gene-environment interactions. It includesa presentation of existing approaches for this problem and a contribution of the thesis. Thefourth chapter brings off the problem of meta-analysis. A definition of the problem and anoverview of the existing approaches are presented. Then, a new approach is introduced.The fifth chapter explains the pleiotropy studies and how the method presented in theprevious chapter is suited for this kind of analysis. The last chapter compiles conclusionsand research lines for the future.

The environment for obtaining information and providing statistical data for policy makers and the public has changed significantly in the past decade, raising questions about the fundamental survey paradigm that underlies federal statistics. New data sources provide opportunities to develop a new paradigm that can improve timeliness, geographic or subpopulation detail, and statistical efficiency. It also has the potential to reduce the costs of producing federal statistics. The panel's first report described federal statistical agencies' current paradigm, which relies heavily on sample surveys for producing national statistics, and challenges agencies are facing; the legal frameworks and mechanisms for protecting the privacy and confidentiality of statistical data and for providing researchers access to data, and challenges to those frameworks and mechanisms; and statistical agencies access to alternative sources of data. The panel recommended a new approach for federal statistical programs that would combine diverse data sources from government and private sector sources and the creation of a new entity that would provide the foundational elements needed for this new approach, including legal authority to access data and protect privacy. This second of the panel's two reports builds on the analysis, conclusions, and recommendations in the first one. This report assesses alternative methods for implementing a new approach that would combine diverse data sources from government and private sector sources, including describing statistical models for combining data from multiple sources; examining statistical and computer science approaches that foster privacy protections; evaluating frameworks for assessing the quality and utility of alternative data sources; and various models for implementing the recommended new entity. Together, the two reports offer ideas and recommendations to help federal statistical agencies examine and evaluate data from alternative sources and then combine them as appropriate to provide the country with more timely, actionable, and useful information for policy makers, businesses, and individuals.

Handbook of Statistical Analysis: AI and ML Applications, third edition, is a comprehensive introduction to all stages of data analysis, data preparation, model building, and model evaluation. This valuable resource is useful to students and professionals across a variety of fields and settings: business analysts, scientists, engineers, and researchers in academia and industry. General descriptions of algorithms together with case studies help readers understand technical and business problems, weigh the strengths and weaknesses of modern data analysis algorithms, and employ the right analytical methods for practical application. This resource is an ideal guide for users who want to address massive and complex datasets with many standard analytical approaches and be able to evaluate analyses and solutions objectively. It includes clear, intuitive explanations of the principles and tools for solving problems using modern analytic techniques; offers accessible tutorials; and discusses their application to real-world problems. - Brings together, in a single resource, all the information a beginner needs to understand the tools and issues in data analytics to build successful predictive analytic solutions - Provides in-depth descriptions and directions for performing many data preparation operations necessary to generate data sets in the proper form and format for submission to modeling algorithms - Features clear, intuitive explanations of standard analytical tools and techniques and their practical applications - Provides a number of case studies to guide practitioners in the design of analytical applications to solve real-world problems in their data domain - Offers valuable tutorials on the book webpage with step-by-step instructions on how to use suggested tools to build models - Provides predictive insights into the rapidly expanding "Intelligence Age" as it takes over from the "Information Age," enabling readers to easily transition the book's content into the tools of the future

Development Research in Practice leads the reader through a complete empirical research project, providing links to continuously updated resources on the DIME Wiki as well as illustrative examples from the Demand for Safe Spaces study. The handbook is intended to train users of development data how to handle data effectively, efficiently, and ethically. “In the DIME Analytics Data Handbook, the DIME team has produced an extraordinary public good: a detailed, comprehensive, yet easy-to-read manual for how to manage a data-oriented research project from beginning to end. It offers everything from big-picture guidance on the determinants of high-quality empirical research, to specific practical guidance on how to implement specific workflows—and includes computer code! I think it will prove durably useful to a broad range of researchers in international development and beyond, and I learned new practices that I plan on adopting in my own research group.†? —Marshall Burke, Associate Professor, Department of Earth System Science, and Deputy Director, Center on Food Security and the Environment, Stanford University “Data are the essential ingredient in any research or evaluation project, yet there has been too little attention to standardized practices to ensure high-quality data collection, handling, documentation, and exchange. Development Research in Practice: The DIME Analytics Data Handbook seeks to fill that gap with practical guidance and tools, grounded in ethics and efficiency, for data management at every stage in a research project. This excellent resource sets a new standard for the field and is an essential reference for all empirical researchers.†? —Ruth E. Levine, PhD, CEO, IDinsight “Development Research in Practice: The DIME Analytics Data Handbook is an important resource and a must-read for all development economists, empirical social scientists, and public policy analysts. Based on decades of pioneering work at the World Bank on data collection, measurement, and analysis, the handbook provides valuable tools to allow research teams to more efficiently and transparently manage their work flows—yielding more credible analytical conclusions as a result.†? —Edward Miguel, Oxfam Professor in Environmental and Resource Economics and Faculty Director of the Center for Effective Global Action, University of California, Berkeley “The DIME Analytics Data Handbook is a must-read for any data-driven researcher looking to create credible research outcomes and policy advice. By meticulously describing detailed steps, from project planning via ethical and responsible code and data practices to the publication of research papers and associated replication packages, the DIME handbook makes the complexities of transparent and credible research easier.†? —Lars Vilhuber, Data Editor, American Economic Association, and Executive Director, Labor Dynamics Institute, Cornell University

This step-by-step guide shows you how to use R to get data analysis right. The book explores the entire process of analysis, covering key steps from preparing your data to putting your analysis together and writing up your findings. It helps you get to grips with doing different statistical techniques in R and: Equips you with practical data visualisation tools to create graphs and tables. Shows you how to prepare and present your research for assessment, publication and dissemination. Covers key issues facing today’s social scientists, such as making research reproducible. Features include an introduction to each chapter, and end-of-chapter exercises to check your understanding of the material. The online resources for this text include data sets that you can perform your own analysis on, and links to publications that are relevant to programming with R. A good starting point for any postgraduate student conducting a research project, this book will help you develop your statistics and programming knowledge and get quickly up to speed.