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Mrs. Jacobson here focuses upon families who settled along the Tombigbee River, an area which today occupies all or part of the Alabama counties of Marion, Fayette, Lamar, Tuscaloosa, Greene, Pickens, and Sumter; and the Mississippi counties of Lee, Itawamba, Monroe, Webster, Clay, Choctaw, Oktibbeha, Lowndes, Winston, and Noxubee. She covers the founding of each of the seventeen counties comprising the Tombigbee River area, with references to the region's indigenous Creeks, Chocktaws, Chickasaws and Cherokees; the phases of French, Spanish and British settlement; and the consolidation of the region under U.S. control following the War of 1812. Doubtless of greatest interest to researchers will be the author's genealogical and biographical essays on twenty-two pioneer families of the region.