The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Complex Systems are natural systems that science is unable to describe exhaustively. Examples of Complex Systems are both unicellular and multicellular living beings; human brains; human immune systems; ecosystems; human societies; the global economy; the climate and geology of our planet. This book is an account of a marvelous interdisciplinary journey the author made to understand properties of the Complex Systems. He has undertaken his trip, equipped with the fundamental principles of physical chemistry, in particular, the Second Law of Thermodynamics that describes the spontaneous evolution of our universe, and the tools of Non-linear dynamics. By dealing with many disciplines, in particular, chemistry, biology, physics, economy, and philosophy, the author demonstrates that Complex Systems are intertwined networks, working in out-of-equilibrium conditions, which exhibit emergent properties, such as self-organization phenomena and chaotic behaviors in time and space.

Scientists and philosophers have long struggled to answer the questions of when human life begins and when human life has inherent value. The phenomenon of identical (monozygotic) twinning presents a significant challenge to the view that human life and human personhood begin at conception. The fact that a single embryo can split to generate two (or more) genetically identical embryos seems to defy the notion that prior to splitting an embryo can be a single human individual. In Untangling Twinning, Maureen Condic looks at the questions raised by human twinning based on a unique synthesis of molecular developmental biology and Aristotelian philosophy. She begins with a brief historical analysis of the current scientific perspective on the embryo and proceeds to address the major philosophic and scientific concerns regarding human twinning and embryo fusion: Is the embryo one human or two (or even more)? Does the original embryo die, and if not, which of the twins is the original? Who are the parents of the twins? What do twins, chimeras, cloning, and asexual reproduction in humans mean? And what does the science of human embryology say about human ensoulment, human individuality, and human value? Condic's original approach makes a unique contribution to the discussion of human value and human individuality, and offers a clear, evidence-based resolution to questions raised by human twinning. The book is written for students and scholars of bioethics, scientists, theologians, and attorneys who are involved in questions surrounding the human embryo.

Human beings generally attribute any physical, mental, or financial catastrophe to the random punitive decree of God, including death. All religions speak about destiny. In this book, I have demonstrated that whatever happens to us are determined by our genetic makeup and the DNA. Of course, the genes and DNA are created by God Himself who is the cause of all causations. In different religions, there is mention of an angel of death, whether this angels causes death or just receives the soul at the time of death is not clear. I have pointed out that natural cause of death is a function of the deteriorating telomere at the end of the chromosome. The other deaths due to accidents, epidemics, famine, and natural disasters are due to natural causes and is self-explanatory. I have mentioned the influence of epigenetics in our gene expression. The influence of epigenetics was recently confirmed in space travel as reported by NASA. This book also alludes to the fact that God does not interfere in our day-to-day activities and that is left for our free will.

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.

Untangling Smart Cities: From Utopian Dreams to Innovation Systems for a Technology-Enabled Urban Sustainability helps all key stakeholders understand the complex and often conflicting nature of smart city research, offering valuable insights for designing and implementing strategies to improve the smart city decision-making processes. The book drives the reader to a better theoretical and practical comprehension of smart city development, beginning with a thorough and systematic analysis of the research literature published to date. It addition, it provides an in-depth understanding of the entire smart city knowledge domain, revealing a deeply rooted division in its cognitive-epistemological structure as identified by bibliometric insights. Users will find a book that fills the knowledge gap between theory and practice using case study research and empirical evidence drawn from cities considered leaders in innovative smart city practices.