Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

NEW YORK TIMES BESTSELLER • Read with Jenna Book Club Pick as Featured on Today • As a young mother facing a terminal diagnosis, Julie Yip-Williams began to write her story, a story like no other. What began as the chronicle of an imminent and early death became something much more—a powerful exhortation to the living. “An exquisitely moving portrait of the daily stuff of life.”—The New York Times Book Review (Editors’ Choice) NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Time • Real Simple • Good Housekeeping That Julie Yip-Williams survived infancy was a miracle. Born blind in Vietnam, she narrowly escaped euthanasia at the hands of her grandmother, only to flee with her family the political upheaval of her country in the late 1970s. Loaded into a rickety boat with three hundred other refugees, Julie made it to Hong Kong and, ultimately, America, where a surgeon at UCLA gave her partial sight. She would go on to become a Harvard-educated lawyer, with a husband, a family, and a life she had once assumed would be impossible. Then, at age thirty-seven, with two little girls at home, Julie was diagnosed with terminal metastatic colon cancer, and a different journey began. The Unwinding of the Miracle is the story of a vigorous life refracted through the prism of imminent death. When she was first diagnosed, Julie Yip-Williams sought clarity and guidance through the experience and, finding none, began to write her way through it—a chronicle that grew beyond her imagining. Motherhood, marriage, the immigrant experience, ambition, love, wanderlust, tennis, fortune-tellers, grief, reincarnation, jealousy, comfort, pain, the marvel of the body in full rebellion—this book is as sprawling and majestic as the life it records. It is inspiring and instructive, delightful and shattering. It is a book of indelible moments, seared deep—an incomparable guide to living vividly by facing hard truths consciously. With humor, bracing honesty, and the cleansing power of well-deployed anger, Julie Yip-Williams set the stage for her lasting legacy and one final miracle: the story of her life. Praise for The Unwinding of the Miracle “Everything worth understanding and holding on to is in this book. . . . A miracle indeed.”—Kelly Corrigan, New York Times bestselling author “A beautifully written, moving, and compassionate chronicle that deserves to be read and absorbed widely.”—Siddhartha Mukherjee, Pulitzer Prize–winning author of The Emperor of All Maladies

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. - Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers - Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field - Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and newcomers in the field of cancer metastasis

In Enduring Cancer Dwaipayan Banerjee explores the efforts of Delhi's urban poor to create a livable life with cancer as patients and families negotiate an overextended health system unequipped to respond to the disease. Owing to long wait times, most urban poor cancer patients do not receive a diagnosis until it is too late to treat the disease effectively. Drawing on ethnographic fieldwork in the city's largest cancer care NGO and at India's premier public health hospital, Banerjee describes how, for these patients, a cancer diagnosis is often the latest and most serious in a long series of infrastructural failures. In the wake of these failures, Banerjee tracks how the disease then distributes itself across networks of social relations, testing these networks for strength and vulnerability. Banerjee demonstrates how living with and alongside cancer is to be newly awakened to the fragility of social ties, some already made brittle by past histories, and others that are retested for their capacity to support.

Although billions of dollars are being spent to find a cure for AIDS, and many drugs are now available for its treatment, millions of people worldwide continue to suffer and die from this disease. Unraveling AIDS is a timely and well-researched book that addresses a wide range of issues regarding the AIDS pandemic. Perhaps most important, the authors explore alternative therapies that appear to be safer, more effective, and less costly than the current generation of AIDS pharmaceuticals.

Provides information on the history of Lyme disease focusing on the scientific processes involved in its discovery.