Traces the decade-long recovery journey of a September 11 survivor who suffered burns on more than eighty percent of her body, describing her experiences during the attacks and the ways she needed to change to renew her commitments to life and her loved ones.

In this update to the 2011 New York Times Bestselling book, the reader will find: - Timely new information about Manning's struggles within the healthcare system - Additional details about the author's childhood - And an emotional new essay from the author about her father, who died shortly after the book's publication A survivor's awe-inspiring story of how she overcame tragedy and re-created herself as a wife, mother, and woman She was a hardworking business woman, had a loving husband and an infant son, and a confidence born of intelligence and beauty. But on 9/11, good fortune was no match for catastrophe. When a wall of flame at the World Trade Center burned more than 80 percent of her body, Lauren Manning began a ten-year journey of survival and rebirth that tested her almost beyond human endurance. Long before that infamous September day, Manning learned the importance of perseverance, relentless hard work, and a deep faith in oneself. So when the horrific moment of her near-death arrived, she possessed the strength and resilience to insist that she would not yield--not to the terrorists, not to the long odds, not to the bottomless pain and exhaustion. But as the difficult months and years went by, she came to understand that she had to do more than survive. She needed to undergo a complete transformation, one that would allow her to embrace her life and her loved ones in an entirely new way.

Early on the morning of September 11, 2001, Lauren Manning-a wife, the mother of a ten-month-old son, and a senior vice president and partner at Cantor Fitzgerald-came to work, as always, at One World Trade Center. As she stepped into the lobby, a fireball exploded from the elevator shaft, and in that split second her life was changed forever. Lauren was burned over 82.5 percent of her body. As he watched his wife lie in a drug-induced coma in the ICU of the Burn Center at New York-Presbyterian Hospital, Greg Manning began writing a daily journal. In the form of e-mails to family, friends, and colleagues, he recorded Lauren’s harrowing struggle-and his own tormented efforts to make sense of an act that defies all understanding. This book is that e-mail diary: detailed, intimate, inspiring messages that end, always, as if a prayer for a happy outcome: LOVE, GREG & LAUREN We share this story day by astonishing day. Greg writes of the intricate surgeries, the painful therapies, and the constant risk of infection Lauren endured. Through his eyes we come to know the doctors, nurses, aides, and therapists who cared for her around the clock with untiring devotion and sensitivity. We also come to know the families with whom he shared wrenching hospital vigils for their own loved ones who were waging a battle that some would not win. It was, most of all, Greg’s belief that Lauren would win her brave fight for life that kept him writing. Through his eyes we see what she could not-their toddler’s first steps, the video of his first birthday party, the compassionate messages of hope from around the world. And we are there as Lauren gradually emerges into awareness, signaling first with her eyes, then with smiles, her understanding of the words Greg speaks to her, the poems he recites, the songs he plays. Most miraculously, we are there when Lauren walks out of the Burn Center. The world knows all too well both the nightmare and the heroism that have marked this terrible time in history. But no account of September 11 matches the astonishing personal story Greg Manning records in these spontaneous and heartfelt pages. It is a story that invites us to share, e-mail after e-mail, the perilous course of a mortally wounded woman who by sheer will and courage emerges from near death because she is determined to live for her husband and her son. And it is equally the story of a man who, as he stays by her side through these long weeks and months, discovers anew the depth of his love and admiration for the woman who becomes his hero.

People think you have it all together. What these people don’t understand is how exhausting it feels to make it look that way. The pressure to keep it all going is intense. You feel unfulfilled and don’t believe you measure up to others. You’re constantly searching for the secret to experience confidence in your own skin. Despite your have-it-all-together life, you can’t figure out how to accept or perfect yourself. You’ve tried diets, intense exercise, shopping, and stuffing brownies in your face. Yet nothing fills the hole deep inside, and you worry, Will I ever be enough? You’ve come to the right place. In Letting Go of Leo, Simi Botic gets personal about what she’s experienced and learned. She shares stories about eating a jar of peanut butter without choking to death. Stories about her thighs rubbing together. Stories of living a fantasy where she would marry Leo DiCaprio and win an Oscar. Stories of realizing that real life can be better than any fantasy, that she could show up for the good stuff and the hard stuff and, most importantly, for herself. Simi used to freak out about food, her body, and not being perfect enough. She freaks out a lot less now. In Letting Go of Leo, she shares how she broke up with perfection—and how you can too.

This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)