The author of The Warrior Diet presents a revolutionary nutrition and exercise program that can improve your health, longevity, and athletic performance Provocatively written yet grounded in science, Unlock Your Muscle Gene is a revolutionary guide to physical transformation and the latest information on muscle conditioning, weight loss, and anti-aging strategies. According to Ori Hofmekler, we need to learn how to trigger the genes that retain and develop our muscles and extend our lives—we need to unleash this innate program that transforms pain to power and makes our bodies thrive. Hofmekler exposes the false theories behind modern fitness and presents the actual biological principles upon which human diet and training should be based. He also details how to combine foods; the right meal timing and meal size; why we need to separate AM foods and PM foods; the ideal fuel to prevent “hitting the wall”; how long and how often to train; and whether we can develop a super-muscle fiber hybrid with unmatched strength and durability. Unlock Your Muscle Gene will inspire you on your path to a stronger, healthier, biologically younger body.

"Provocatively written yet grounded in science, Unlock Your Muscle Gene argues that human fitness is a well-defined system rooted in our biology and programmed in our genes. We all possess the genes that retain and develop muscle and extend our lives, but to turn them on we need to learn how to use the right nutritional and physical triggers. Doing so unleashes innate mechanisms that literally transform pain to power, weakness to strength, and sickness to health. Fitness expert Ori Hofmekler describes the main causes of muscle degradation and aging and offers specific exercise and nutrition practices for counteracting them. He argues that the human body is programmed for hardship rather than leisure and emphasizes the primary roles of hunger and hardship in triggering the mechanisms that make our bodies thrive. Hofmekler also details how to combine food; the right meal timing and meal size; why we need to separate AM foods and PM foods; the ideal fuel to prevent "hitting the wall"; how long and how often to train; and whether we can develop a super muscle fiber hybrid that can outperform any other fiber type. Unlock Your Muscle Gene is both practical and inspiring in pointing the way to a leaner, stronger, healthier body"--

Muscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body. In Muscle Gene Therapy: Methods and Protocols, expert researchers in the field present a collection of techniques aimed at bridging the translational gap in muscle gene therapy between the prevalent rodent models and vitally important larger animal models. Divided into three sections, this volume examines basic protocols for optimizing the muscle gene expression cassette and for evaluating the therapeutic outcomes, new developments in muscle gene therapy technology such as adeno-associated viral vector (AAV), oligonucleotide-mediated exon-skipping, and novel RNA-based strategies, and step-by-step guidance on muscle gene delivery in swine, ovine, canine, and non-human primates. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, detailed, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Muscle Gene Therapy: Methods and Protocols serves as an invaluable resource for graduate students, post-doctoral fellows, and principle investigators pursuing the crucial advancement of muscle disease gene therapy in the hope of someday curing these debilitating disorders.

The author of The Warrior Diet shares his revolutionary approach to physical transformation, offering practical guidance on how to build and maintain a leaner, stronger, and healthier body Diet and fitness books appear at a dizzying rate—and with a wealth of dubious claims—in a culture facing increasing health problems based on a sedentary lifestyle. Ori Hofmekler’s Maximum Muscle, Minimum Fat pulls out of the pack by focusing on the biological principles that dictate muscle gain and fat loss. Written for the widest readership—competitive athletes, bodybuilders, trainers, martial artists, sports nutritionists and coaches, dieters, and anyone concerned about their health—the book builds on the concepts popularized in The Warrior Diet. In simple lay terms, Hofmekler how under-eating and fasting can trigger an anabolic switch that stimulates growth and rejuvenation; how to re-engineer the body at the cellular level to burn fat and build muscles; and how to naturally manipulate the body’s hormones for rapid muscle fusion and faster fat breakdown. He offers smart strategies for: • Taking advantage of hunger to stimulate growth, burn fat, and boost brain power • Turning insulin into a muscle builder instead of a fat gainer • Shattering training and diet plateaus • Improve metabolic function, performance, and your capacity to gain and sustain prime health Challenging most common diet and fitness concepts, Maximum Muscle, Minimum Fat provides a revolutionary way of looking at human performance, shedding new light on how the muscle and fat tissues operate and offering practical information on how to achieve optimal physical health.

I train as many people do to better and improve my physique in the fastest way possible. I love the challenge of weight resistance exercise to see what the human body can achieve in strength and size. I train naturally without the use of drugs, which is the real challenge. It has always been said that you can only build so much muscle without the use of drugs. My aim is to influence your thinking in that you can build more muscle than you ever thought possible once you start working out correctly. The key ingredients to your success are: Training, Rest and Recovery and Diet and Supplementation. Most information around on physical exercise usually either confuses or can even put you on the road to ruin as far as giving you the knowledge you require to constantly improve your muscle mass and conditioning without either vastly over-training or causing serious injury. I am going to try and change your mindset on how to train with weights to achieve the goals that you set out to attain from your exercise programme. So read this book and apply the theories, it will change the way you look at training and exercise forever Taken from the Introduction by Craig Hartley

The New York Times bestseller – with a new afterword about early specialization in youth sports – from the author of Range: Why Generalists Triumph in a Specialized World. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration of athletic success and the so-called 10,000-hour rule, David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving it. Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.