Basic Aspects.- 1 The Epidermal Barrier and Strategies for Surmounting It: An Overview.- 2 Stem Cells, Differentiation and Renewal Kinetics of Keratinocytes: Implications for Cutaneous Gene Therapy.- 3 Relevant Animal Models for Skin Gene Therapy.- 4 Nonviral Gene Transfer into the Skin.- 5 Safety and Pharmacokinetics of Naked Plasmid DNA: Studies on Dissemination and Ectopic Expression.- 6 Uptake of DNA by Keratinocytes.- Treatment of Skin Diseases.- Gene Therapy of Inherited Skin Diseases.- Gene Transfer Strategies in Tissue Repair.- Systemic Effects of Skin Gene Therapy.- The Use of Skin-Directed Gene Therapy in the Treatment of Systemic Diseases.- Keratinocyte Gene Therapy Using Cytokine Genes.- Genetic Vaccination Using the Skin.- Principles of Genetic Immunization.- Systematic Modulation of Immune Responses by CpG DNA.- Genetic and Dendritic Cell Vaccination as a Novel Therapy for Melanoma.- Molecular Strategies Interfering with Tumor Progression of Melanoma and Improving Anti-Tumor Immunity.- Prophylactic and Therapeutic DNA Vaccines Against Infectious Diseases.

In recent decades Multimedia processing has emerged as an important technology to generate content based on images, video, audio, graphics, and text. This book is a compilation of the latest trends and developments in the field of computational intelligence in multimedia processing. The edited book presents a large number of interesting applications to intelligent multimedia processing of various Computational Intelligence techniques including neural networks and fuzzy logic.

With this book we aim at describing and analysing the selection, daily life, networks and values of local top political leaders in seventeen European countries. The empirical nourishment to the investigation into town halls across Europe is a survey conducted in 2003 with mayors and corresponding top local political leaders. The data covering responses from 2700 leaders is a unique and rich material allowing descriptions and analyses pursuing a number of lines of inquiry.

This book introduces readers to industrially important enzymes and discusses in detail their structures and functions, as well as their manifold applications. Due to their selective biocatalytic capabilities, enzymes are used in a broad range of industries and processes. The book highlights selected enzymes and their applications in agriculture, food processing and discoloration, as well as their role in biomedicine. In turn, it discusses biochemical engineering strategies such as enzyme immobilization, metabolic engineering, and cross-linkage of enzyme aggregates, and critically weighs their pros and cons. Offering a wealth of information, and stimulating further research by presenting new concepts on enzymatic catalytic functions in basic and applied contexts, the book represents a valuable asset for researchers from academia and industry who are engaged in biochemical engineering, microbiology and biotechnology.

Adding some 20 percent to the original content, this is a completely updated edition of Steven Weisenburger's indispensable guide to Thomas Pynchon's Gravity's Rainbow. Weisenburger takes the reader page by page, often line by line, through the welter of historical references, scientific data, cultural fragments, anthropological research, jokes, and puns around which Pynchon wove his story. Weisenburger fully annotates Pynchon's use of languages ranging from Russian and Hebrew to such subdialects of English as 1940s street talk, drug lingo, and military slang as well as the more obscure terminology of black magic, Rosicrucianism, and Pavlovian psychology. The Companion also reveals the underlying organization of Gravity's Rainbow--how the book's myriad references form patterns of meaning and structure that have eluded both admirers and critics of the novel. The Companion is keyed to the pages of the principal American editions of Gravity's Rainbow: Viking/Penguin (1973), Bantam (1974), and the special, repaginated Penguin paperback (2000) honoring the novel as one of twenty "Great Books of the Twentieth Century."

What motivates suicide bombers in Iraq and around the world? Can winning the hearts and minds of local populations stop them? Will the phenomenon spread to the United States? These vital questions are at the heart of this important book. Mia Bloom examines the use, strategies, successes, and failures of suicide bombing in Asia, the Middle East, and Europe and assesses the effectiveness of government responses. She argues that in many instances the efforts of Israel, Russia, and the United States in Iraq have failed to deter terrorism and suicide bombings. Bloom also considers how terrorist groups learn from one another, how they respond to counterterror tactics, the financing of terrorism, and the role of suicide attacks against the backdrop of larger ethnic and political conflicts. Dying to Kill begins with a review of the long history of terrorism, from ancient times to modernity, from the Japanese Kamikazes during World War II, to the Palestinian, Tamil, Iraqi, and Chechen terrorists of today. Bloom explores how suicide terror is used to achieve the goals of terrorist groups: to instill public fear, attract international news coverage, gain support for their cause, and create solidarity or competition between disparate terrorist organizations. She contends that it is often social and political motivations rather than inherently religious ones that inspire suicide bombers. In her chapter focusing on the increasing number of women suicide bombers and terrorists, Bloom examines Sri Lanka, where 33 percent of bombers have been women; Turkey, where the PKK used women feigning pregnancy as bombers; and the role of the Black Widows in the Chechen struggle against Moscow. The motives of individuals, whether religious or nationalist, are important but the larger question is, what external factors make it possible for suicide terrorism to flourish? Bloom describes these conditions and develops a theory of why terrorist tactics work in some instances and fail in others.