Understanding Lung Acinar Micromechanics in Health and Disease: Linking Quantitative Imaging and Organ Scale Mechanics by Computational Modeling
Title | Understanding Lung Acinar Micromechanics in Health and Disease: Linking Quantitative Imaging and Organ Scale Mechanics by Computational Modeling PDF eBook |
Author | Matthias Ochs |
Publisher | Frontiers Media SA |
Pages | 220 |
Release | 2021-02-26 |
Genre | Science |
ISBN | 2889665216 |
Physics-Based Computational Modeling of Mechanics and Perfusion in COVID-19 Infected Lungs
Title | Physics-Based Computational Modeling of Mechanics and Perfusion in COVID-19 Infected Lungs PDF eBook |
Author | Elizabeth Dimbath |
Publisher | |
Pages | 0 |
Release | 2022 |
Genre | |
ISBN |
SARS-CoV-2 is the newest virus to lead to severe respiratory illness and reach global pandemic status in its spread. Histopathological studies as well as global lung dynamics of the disease state of COVID-19 resemble acute respiratory distress syndrome but with some marked differences that have yet to be fully understood. Studying COVID-19 infected lung mechanics and perfusion provides a unique opportunity to advance our foundational knowledge of lung dynamics in a disease state. Lung mechanics emerge from the complex structure of the microscale lung; hence, understanding lung micro- and meso-scale mechanical properties is required to shed light on the macroscale mechanical properties of the whole lung. Current limitations of in vivo and in vitro methods can make it difficult to understand the effects of viral damage on dynamic function of the microscale lung. Thus, computational modeling of microscale lung mechanics in disease may provide new insights into whole lung dynamics. To this end, this thesis provides a review on the current knowledge on COVID-19 lung mechanics and develops physics-based computer models of the healthy and COVID-19 affected micro and meso-scale lung in addition to multi-scale perfusion-ventilation models. A fully resolved model of the mesoscale lung is used to reconcile the range of reported mechanical properties for healthy lung mechanics across the meso- and microscale. Furthermore, a reduced dimensional approach is used to model the acinus and account for the ventilation, perfusion, and diffusion processes that contribute to gas exchange function in the lung. The acinar model is utilized in a multiscale lung model to gain insight into COVID-19 lung mechanics in a patient-specific approach. These models provide informative tools for lung mechanics researchers and are a foundational step towards understanding and modeling the complex microscale lung damage that produces the spectrum of COVID-19 disease symptoms.
Lung Mechanics
Title | Lung Mechanics PDF eBook |
Author | Jason H. T. Bates |
Publisher | |
Pages | 220 |
Release | 2009 |
Genre | Electronic books |
ISBN | 9780511592614 |
With mathematical and computational models furthering our understanding of lung mechanics, function and disease, this book provides an all-inclusive introduction to the topic from a quantitative standpoint. Focusing on inverse modeling, the reader is guided through the theory in a logical progression, from the simplest models up to state-of-the-art models that are both dynamic and nonlinear. Key tools used in biomedical engineering research, such as regression theory, linear and nonlinear systems theory, and the Fourier transform, are explained. Derivations of important physical principles, such as the Poiseuille equation and the wave speed equation, from first principles are also provided. Example applications to experimental data throughout illustrate physiological relevance, whilst problem sets at the end of each chapter provide practice and test reader comprehension. This book is ideal for biomedical engineering and biophysics graduate students and researchers wishing to understand this emerging field.
Micro-computed Tomography (micro-CT) in Medicine and Engineering
Title | Micro-computed Tomography (micro-CT) in Medicine and Engineering PDF eBook |
Author | Kaan Orhan |
Publisher | Springer |
Pages | 312 |
Release | 2019-07-25 |
Genre | Medical |
ISBN | 3030166414 |
This book focuses on applications of micro CT, CBCT and CT in medicine and engineering, comprehensively explaining the basic principles of these techniques in detail, and describing their increasing use in the imaging field. It particularly highlights the scanning procedure, which represents the most crucial step in micro CT, and discusses in detail the reconstruction process and the artifacts related to the scanning processes, as well as the imaging software used in analysis. Written by international experts, the book illustrates the application of micro CT in different areas, such as dentistry, medicine, tissue engineering, aerospace engineering, geology, material engineering, civil engineering and additive manufacturing. Covering different areas of application, the book is of interest not only to specialists in the respective fields, but also to broader audience of professionals working in the fields of imaging and analysis, as well as to students of the different disciplines.
Nanoparticles in the Lung
Title | Nanoparticles in the Lung PDF eBook |
Author | Akira Tsuda |
Publisher | CRC Press |
Pages | 403 |
Release | 2014-12-19 |
Genre | Medical |
ISBN | 1439892806 |
Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding
MicroComputed Tomography
Title | MicroComputed Tomography PDF eBook |
Author | Stuart R. Stock |
Publisher | CRC Press |
Pages | 366 |
Release | 2008-12-23 |
Genre | Technology & Engineering |
ISBN | 1420058770 |
Due to the availability of commercial laboratory systems and the emergence of user facilities at synchrotron radiation sources, studies of microcomputed tomography or microCT have increased exponentially. MicroComputed Technology provides a complete introduction to the technology, describing how to use it effectively and understand its results. The first part of the book focuses on methodology, covering experimental methods, data analysis, and visualization approaches. The second part addresses various microCT applications, including porous solids, microstructural evolution, soft tissue studies, multimode studies, and indirect analyses. The author presents a sufficient amount of fundamental material so that those new to the field can develop a relative understanding of how to design their own microCT studies. One of the first full-length references dedicated to microCT, this book provides an accessible introduction to field, supplemented with application examples and color images.
Integration in Respiratory Control
Title | Integration in Respiratory Control PDF eBook |
Author | Marc Poulin |
Publisher | Springer |
Pages | 0 |
Release | 2010-11-19 |
Genre | Medical |
ISBN | 9781441925299 |
This volume comprises the proceedings of the 10th Oxford Conference held at Lake Louise, Alberta, Canada, in September, 2006. It contains the most up-to-date research in cardio-respiratory control and its content spans the disciplines of respiratory physiology, neurobiology, modeling, and biomedical engineering. The volume will be of interest to clinicians working with patients with breathing disorders.