Around two hundred years after her discovery by the Brothers Grimm, Sleeping Beauty has lost her happily ever after. Mortal authors can enslave fairy tale folk as muses with the flash of a camera, and Beauty has long since left her enchanted castle for the anonymity of city life in modern Washington, D.C. Worse, her relationship with Prince Charming is on the rocks; her crush on her best friend Lancelot is going nowhere; and her boss, Titania, is about to fire her from the Tale’s End Bookstore and Café, where she lives and works as a barista. As if that weren't enough, alone among the immortal fairy folk, Beauty is changing. She’s not sure how, or why, but she isn't the same person who walked out of the Dark Forest and it terrifies her. If she’s no longer a princess – if her life is no longer a fairy tale – will there be a home for her with the fairy folk when the last words are written?

This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring’s health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health.

This volume offers the most comprehensive coverage on fetal programming. Chapters are written by authors of international and national standing, leaders in the field and trendsetters. The clinical relevance of the current research is emphasized in each chapter, which also contains key points, key words, and concise summaries for ease of learning. Fetal programming affects conditions in the immediate postnatal period, as well as in later life and adulthood. These conditions include cardiovascular disease, frank hypertension, stroke, dyslipidemia, coagulopathy, increased insulin resistance-metabolic syndrome, type-2 diabetes, leukemia, testicular cancer, prostate cancer, breast cancer, polycystic ovary syndrome, precocious puberty, impaired immune function, renal disease, lung disease, and osteoporosis. Neuropathologies, behavioral and mental deficiencies, schizophrenia, and depression have also been reported in adults who were exposed to nutritional inadequacies in utero. Diet, Nutrition and Fetal Programming provides an overview on the effects of fetal programming on disease, and comprehensive looks at maternal nutrition factors and fetal programming effects on brain and behavior, and physiology and disease. It also provides an in depth look at specific nutrient restrictions and supplements on physiology and disease, the effects of maternal disease on fetal programming, mechanisms of programming, and a special section on the international aspects and policies on fetal programming.

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances. - Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions - Fills an existing gap in the literature by serving as a "one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse - Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, full references - Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body

Caffeine for Sports Performance is the definitive resource for all your questions regarding caffeine and its impact on sports performance. Based on the most recent research, studies, and guidelines, this guide is ideal for athletes and fitness enthusiasts looking to improve training and competition. Inside you will find these features: • The history of how caffeine has become the most widely used drug in the world • The pros and cons of using caffeine, including habitual daily caffeine intake, to boost sports performance • Personal usage guides that can be applied to various sports or scenarios of caffeine use in training and competition • Health advice regarding caffeine use • Performance effects of caffeine use • Safety considerations and potential risks • Best and worst sources for caffeine Caffeine for Sports Performance provides plenty of practical tips for using caffeine. In particular you will find sidebars that feature interviews with top athletes and coaches who have interesting stories to tell regarding their experiences using caffeine. You will also gain new insight into current attitudes towards caffeine and how those attitudes have changed over the years. Caffeine for Sports Performance gives you all you need to understand and use caffeine to get the most out of your sport.