A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presents an overview of exploring gene regulatory networks, chromatin, and miRNAs. Information about state-of-the-art techniques for the determination of TF - cis-element interactions in vivo and in silico give cutting edge insights on how genomic-scale research is being approached. The Analysis of Regulatory DNA provides readers with both the necessary background knowledge and provocative, up-to-date insights aimed at sparking new and vibrant experimental designs for understanding and predicting cis-elements in the eukaryotic genome.

This volume presents a sophisticated set of archival, forensic, and excavation methods to identify both individuals and group affiliations—cultural, religious, and organizational—in a multiethnic historical cemetery. Based on an extensive excavation project of more than 1,000 nineteenth-century burials in downtown Tucson, Arizona, the team of historians, archaeologists, biological anthropologists, and community researchers created an effective methodology for use at other historical-period sites. Comparisons made with other excavated cemeteries strengthens the power of this toolkit for historical archaeologists and others. The volume also sensitizes archaeologists to the concerns of community and cultural groups to mortuary excavation and outlines procedures for proper consultation with the descendants of the cemetery’s inhabitants. Copublished with SRI Press

Despite the non-territorialised strategic goals of the EU 2020 Strategy, the long-term aim of EU Cohesion Policy to promote harmonious development of the European territory – social, economic, and ‘territorial cohesion’ – remains a central goal of achieving a more cohesive EU territory. This book examines the ‘territorial dimension’ of EU Cohesion Policy, specifically assessing territorial impacts at the various spatial levels, engaging theoretically and empirically with the notion and role of the ‘territorial dimension’ within a strongly fragmented EU policymaking process, and examining more generally EU Cohesion Policy, as the main driver of the EU territorial development process. It provides an updated and fresh theoretical discussion on the precise meaning of the ‘territorial dimension’ of policies and the relatively recent EU policy evaluation technique, known as ‘Territorial Impact Assessment’ (TIA). Assessing the history, relevance, efficiency and effectiveness of these procedures, it presents several empirical findings on the implementation of specific territorial-focus and place-based financial instruments, as part of the Territorial Agendas and the EU goal of achieving a more integrated, territorial approach. This text will be of key interest to scholars, students and practitioners of spatial planning and cohesion policy, European sector policies and European spatial planning, and more broadly to European and EU studies/politics, regional economic geography and public policy.

"English is so illogical!" It is generally believed that English is a language of exceptions. For many, learning to spell and read is frustrating. For some, it is impossible... especially for the 29% of Americans who are functionally illiterate. But what if the problem is not the language itself, but the rules we were taught? What if we could see the complexity of English as a powerful tool rather than a hindrance? --Denise Eide Uncovering the Logic of English challenges the notion that English is illogical by systematically explaining English spelling and answering questions like "Why is there a silent final E in have, large, and house?" and "Why is discussion spelled with -sion rather than -tion?" With easy-to-read examples and anecdotes, this book describes: - the phonograms and spelling rules which explain 98% of English words - how English words are formed and how this knowledge can revolutionize vocabulary development - how understanding the reasons behind English spelling prevents students from needing to guess The author's inspiring commentary makes a compelling case that understanding the logic of English could transform literacy education and help solve America's literacy crisis. Thorough and filled with the latest linguistic and reading research, Uncovering the Logic of English demonstrates why this systematic approach should be as foundational to our education as 1+1=2.

Much has been written about globalization as an economic and political concept. The academic debate looks forward for explanations about the historical roots and development of this emerging phenomenon where the Nation-State’s evolved into a system where nations are ruled by the dynamics of global interdependence. Globalization in the new era is characterized as a process where geographical, political and cultural borders tend to dissolve. The Westphalia notion of sovereignty capitulates against the principle of political subordination as integration of local power ensuring national legitimacy.