NEW YORK TIMES BESTSELLER “Uncontrolled Spread is everything you’d hope: a smart and insightful account of what happened and, currently, the best guide to what needs to be done to avoid a future pandemic." —Wall Street Journal “Informative and well paced.”—The Guardian “An intense ride through the pandemic with chilling details of what really happened. It is also sprinkled with notes of true wisdom that may help all of us better prepare for the future.”—Sanjay Gupta, MD, chief medical correspondent, CNN Physician and former FDA commissioner Scott Gottlieb asks: Has America’s COVID-19 catastrophe taught us anything? In Uncontrolled Spread, he shows how the coronavirus and its variants were able to trounce America’s pandemic preparations, and he outlines the steps that must be taken to protect against the next outbreak. As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced. A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security. Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks. Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.

In this century, the world will conduct an extraordinary experiment in government. In 2050, forty percent of the planet's population will live in just four places: India, China, the European Union, and the United States. These are superstates – polities that are distinguished from normal countries by expansiveness, population, diversity, and complexity. How should superstates be governed? What must their leaders do to hold these immense polities together in the face of extraordinary strains and shocks? Alasdair Roberts looks to history for answers. Superstates, he contends, wrestle with the same problems of leadership, control, and purpose that plagued empires for centuries. But they also bear heavier burdens than empires – including the obligation to improve life for ordinary people and respect human rights. One axiom of history was that empires always died. Size and complexity led to fragility, and imperial rulers improvised constantly to put off the day of reckoning. Leaders of superstates are doing the same today, pursuing radically different strategies for governing at scale that have profound implications for democracy and human rights. History shows that there are ways to govern these sprawling and diverse polities well. But this requires a different way of thinking about the art and methods of statecraft.

"The most revealing pandemic book yet."—The Atlantic The definitive, inside account of the Trump Administration’s response to the Covid-19 pandemic from White House Coronavirus Response Coordinator and Coronavirus Task Force member, Dr. Deborah Birx. In late February 2020, Dr. Deborah Birx—a lifelong federal health official who had worked at the CDC, the State Department, and the US Army across multiple presidential administrations—was asked to join the Trump White House Coronavirus Task Force and assist the already faltering federal response to the Covid-19 pandemic. For weeks, she’d been raising the alarm behind the scenes about what she saw happening in public—from the apparent lack of urgency at the White House to the routine downplaying of the risks to Americans. Once in the White House, she was tasked with helping fix the broken federal approach and making President Trump see the danger this virus posed to all of us. Silent Invasion is the story of what she witnessed and lived for the next year—an eye-opening, inside account, detailed here for the first time, of the Trump Administration’s response to the greatest public health crisis in modern times. Regarded with suspicion in the West Wing from day one, Dr. Birx goes beyond the media speculation and political maneuvering to show what she was really up against in the Trump White House. Digging into the hard-fought victories, the costly mistakes, and the human drama surrounding the administration’s efforts, she examines the forces that crippled efforts to control the virus and explores why these blunders continue to haunt us today. And yet amid the agonizing missteps were bright spots that point the way forward—the fastest vaccine creation in history, governors that put their citizens’ health first, and Tribal Nations that demonstrated the powerful role of community in curbing spread, despite their criminally underfunded healthcare systems. Collectively these successes reveal the valiant work of many who were committed to saving lives, as well as highlighting the dire need to reform our public health institutions, so they are nimble and resilient enough to confront the next pandemic. With the pandemic now moving into its third year confounding two presidential administrations, Dr. Birx presents a story at once urgent and frustratingly unfinished, as Covid-19 continues to put thousands of American lives at risk. The end result is the most comprehensive and extensive accounting to date of the Trump Administration’s struggle to control the biggest health crisis in generations—a revelatory look at how we can learn from our mistakes and prevent this from happening again.

An in-depth guide to prepare your family for the widespread outbreak of any deadly disease like COVID-19 or H1N1. New viruses hop around the globe every year. In 2009–2010, it was H1N1 that infected over sixty million people around the globe. In 2014, Ebola virus had a terrifying 40% mortality rate. In 2020, COVID-19 exploded into a world-wide pandemic despite the best efforts of governments and health organizations.So, what will happen when a pathogen as easily transmitted as coronavirus and as deadly as Ebola emerges? Prepping for a Pandemic provides all the information you need for medical self-reliance. It’s step-by-step guidance covers every important issue, including stocking food, storing water, developing contingency plans, learning first aid and nursing skills, and establishing quarantines and sick rooms. With checklists, tips, and plans, this book outlines the necessary supplies and skills one will need to stay healthy when doctors, hospitals, and the world’s medical infrastructure become overwhelmed or unavailable during a pandemic outbreak.

An in-depth look at genetic alteration in the natural world and the oppositions to it, seen through the case study of a gene drive for malaria. May We Make the World? is an engaging reflection on the history, nature, goal, and meaning of using a new technological idea—CRISPR-based genetic engineering—to alter the genome of the mosquito that carries malaria. This technology, called a “gene drive,” can alter the sex ratio in Anopheles gambiae mosquitoes, the key vector for falciparum, the deadliest form of malaria. P. Falciparum kills 400,000 people a year, largely the poorest children in the world among them. In her sobering examination of the issue, Laurie Zoloth considers the leading ethical arguments for and against gene drives, explores the regulatory efforts that have emerged long in advance of the science, and considers the philosophical questions raised by the struggle to eliminate malaria. The development of a gene drive for malaria will have far-reaching implications for it represents the first use of genetic engineering in the natural world and the first creation of a genetic variant intended to spread in the African wild beyond human control. Drawing on two decades of work, Zoloth brilliantly argues that we can understand the complex moral issues at stake only by carefully reflecting on the science, the nature of the local and global discourse about genetic engineering, and the long history of malaria, which—as it transformed from a worldwide disease to a tropical one—reshaped the world as we know it.

Wer haftet, wenn sich selbst ausbreitende Gentechnik grenzüberschreitende Schäden verursacht? Mit Gene Drives und ähnlichen Verfahren wird es bald möglich sein, das Erbgut wild lebender Arten, Keime und Nutzpflanzen direkt in der Umwelt zu verändern. Dies könnte helfen, drängende Probleme in der öffentlichen Gesundheit, im Naturschutz und in der Ernährungssicherheit zu lösen. Allerdings bergen diese Verfahren auch das Risiko einer unkontrollierten Ausbreitung über Staatsgrenzen hinweg. Anhand einer grundlegenden Untersuchung der einschlägigen Verträge und des Völkergewohnheitsrechts zu Prävention und Haftung für grenzüberschreitende Schäden wird aufgezeigt, dass das derzeit geltende Völkerrecht dieser Herausforderung noch nicht gewachsen ist.

One of the themes of the 20th International Congress of Entomology held in Florence in August 1996 was Ecology and Population Dynamics, with papers presented on single species dynamics, population interactions, and community ecology. This book contains a selection of the papers that were presented, and gives a late-1990s picture of the latest research in this fast developing area.