The series showing Spider-Man teaming up with other superheroes. It is set in the Ultimate Universe. This issue shows Spider-Man teaming up with Fantastic Four, X-Men, Man-Thing, and Dr. Strange.

Humanity now faces mutants, a mysterious sub-species that is gifted with strange and frightening powers. Hidden among the population. they are feared and hated by their human cousins. As rumors and urban myths about their existence spread across the world, the US government creates its own initiative to deal with this threat: the Sentinel Project. Meanwhile two men wage a secret war for the hearts and minds of young mutants everywhere. Charles Xavier has recruited a cadre of students including Cyclops, Jean Grey and Beast, that call themselves the X-Men. But there are others out there, living in fear, struggling to deal with what they are: Ororo Munroe, Bobby Drake and another, more dangerous mutant named Logan. Simultaneously, the terrorist known only as Magneto has assembled The Brotherhood, a militant group dedicated to the overthrow of human authority. A war is on the horizon and these amazing young men and women will decide the future of all humanity! Collects Ultimate X-Men (2000) #1-6.

Collects Marvel Team-Up (2019) #1-6. Kamala Khan puts the “Ms.” into Marvel Team-Up! Ms. Marvel steps into the starring role of one of Marvel’s all-time classic titles — and fittingly, the ever-sociable Spider-Man swings by to hand over the mantle! After a science demonstration at Empire State University goes awry, Ms. Marvel and Spidey find themselves tangled up in the same chaotic adventure. Is it destiny? Or disaster?! And can the two heroes put their heads together and find a way to save the day? Next, the sudden reappearance of Mar-Vell, the first Captain Marvel, draws Carol Danvers and Kamala Khan back together for an out-of-this-world adventure! But is the man behind the mask who he claims to be? And can Ms. Marvel and Captain Marvel stay on the same page long enough to find out?

Collecting all 16 issues of Ultimate Marvel Team-Up, plus the star-studded Ultimate Spider-Man Super Special! Teenager Peter Parker may just have started out in the crime-fighting game, but there are plenty of heroes and villains already doing their thing. And it doesn't take long for Spider-Man to encounter these strange new allies and enemies - including Wolverine, the Hulk, Iron Man, the Punisher, Daredevil, the Fantastic Four, the Man-Thing, the X-Men, Doctor Strange, the Black Widow, Shang-Chi and more! Take a wild tour through the ever-exciting Ultimate universe, as Eisner Award-winning writer Brian Michael Bendis teams up with the comic industry's greatest artistic talents! Through the eyes of Peter Parker, Ultimate Marvel Team-Up showcases all the Ultimate heroes. From uncanny mutants to gleaming Avengers to rampaging green brutes, this volume has it all! Collects Ultimate Marvel Team-Up #1-16 and the Ultimate Spider-Man Super Special.

The heroes of the Marvel Universe are no more. Spider-Man? Wolverine? Captain America? Iron Man? Gone - but the people of the world still need saving; they still need heroes. Make way for The League of Losers! Plus: The team-up you thought you'd never see! Robert Kirkman and Cory Walker's Invincible bounces over to the Marvel Universe for a visit! Collects Marvel Team-Up #14-18.

"Contains material originally published in magazine form as Marvel Team-Up #1-6"--Cover p. [2].