TWO-DIMENSIONAL (2D) NMR METHODS Practical guide explaining the fundamentals of 2D-NMR for experienced scientists as well as relevant for advanced students Two-Dimensional (2D) NMR Methods is a focused work presenting an overview of 2D-NMR concepts and techniques, including basic principles, practical applications, and how NMR pulse sequences work. Contributed to by global experts with extensive experience in the field, Two-Dimensional (2D) NMR Methods provides in-depth coverage of sample topics such as: Basics of 2D-NMR, data processing methods (Fourier and beyond), product operator formalism, basics of spin relaxation, and coherence transfer pathways Multidimensional methods (single- and multiple-quantum spectroscopy), NOESY (principles and applications), and DOSY methods Multiple acquisition strategies, anisotropic NMR in molecular analysis, ultrafast 2D methods, and multidimensional methods in bio-NMR TROSY (principles and applications), field-cycling and 2D NMR, multidimensional methods and paramagnetic NMR, and relaxation dispersion experiments This text is a highly useful resource for NMR specialists and advanced students studying NMR, along with users in research, academic and commercial laboratories that study or conduct experiments in NMR.

From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.

The field of nuclear magnetic resonance spectroscopy has undergone explosive development during the last decade with the advent of new one- and two-dimensional techniques. The author has had extensive experience in the use of these techniques for the structure elucidation of complex natural products, and in this book he gives a comprehensive, up-to-date and very readable account of these developments. The book's scope is very wide. It starts from fundamental principles of modern NMR spectroscopy, describing the instrumentation and its optimum use, and extends to the latest developments such as inverse measurements. Emphasis is on problem-solving so as to be useful to a large number of organic chemists, biochemists and medicinal chemists. The problems and worked solutions at the end of the chapters will help students to gain proficiency in the application of these new techniques. Those who are learning how to operate modern NMR spectrometers will find particularly useful the description of such basic aspects as shimming, probe tuning, and methods for improvement of resolution and sensitivity.

FROM THE PREFACE: Pulse Methods in 1D and 2D Liquid-Phase NMR is written to enable the practicing NMR spectroscopist to understand and apply the varied and powerful new techniques developed in the past few years for obtaining spectra with greatly increased information content and from smaller and smaller samples. The intent is to describe both theory and practice in simple and detailed fashion so that the methods may be critically evaluated and effectively used in any potential application. As methods become more complex they require more instrument time, and it is important to be able to judge whether the investment of this time is justified. It is also essential for the spectroscopist to be in a position to evaluate the capabilities of the instrumentation available, as well as the additional requirements for utilization of particular new methods. The material in this book assumes a knowledge of continuous-wave NMR methods as well as an elementary understanding of the normal pulsed Fourier-transform spectroscopic procedures, together with a knowledge of such related phenomena as the nuclear Overhauser effect. Although much of the treatment is necessarily methematical, this aspect of the presentation has been simplified as much as possible.

The derivation of structural information from spectroscopic data is now an integral part of organic chemistry courses at all Universities. Over recent years, a number of powerful two-dimensional NMR techniques (e.g. HSQC, HMBC, TOCSY, COSY and NOESY) have been developed and these have vastly expanded the amount of structural information that can be obtained by NMR spectroscopy. Improvements in NMR instrumentation now mean that 2D NMR spectra are routinely (and sometimes automatically) acquired during the identification and characterisation of organic compounds. Organic Structures from 2D NMR Spectra is a carefully chosen set of more than 60 structural problems employing 2D-NMR spectroscopy. The problems are graded to develop and consolidate a student’s understanding of 2D NMR spectroscopy. There are many easy problems at the beginning of the collection, to build confidence and demonstrate the basic principles from which structural information can be extracted using 2D NMR. The accompanying text is very descriptive and focussed on explaining the underlying theory at the most appropriate level to sufficiently tackle the problems. Organic Structures from 2D NMR Spectra Is a graded series of about 60 problems in 2D NMR spectroscopy that assumes a basic knowledge of organic chemistry and a basic knowledge of one-dimensional NMR spectroscopy Incorporates the basic theory behind 2D NMR and those common 2D NMR experiments that have proved most useful in solving structural problems in organic chemistry Focuses on the most common 2D NMR techniques – including COSY, NOESY, HMBC, TOCSY, CH-Correlation and multiplicity-edited C-H Correlation. Incorporates several examples containing the heteronuclei 31P, 15N and 19F Organic Structures from 2D NMR Spectra is a logical follow-on from the highly successful “Organic Structures from Spectra” which is now in its fifth edition. The book will be invaluable for students of Chemistry, Pharmacy, Biochemistry and those taking courses in Organic Chemistry. Also available: Instructors Guide and Solutions Manual to Organic Structures from 2D NMR Spectra