Tumor Microenvironment and Cellular Stress
Title | Tumor Microenvironment and Cellular Stress PDF eBook |
Author | Constantinos Koumenis |
Publisher | Springer Science & Business Media |
Pages | 293 |
Release | 2013-11-23 |
Genre | Medical |
ISBN | 146145915X |
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Tumor Microenvironment
Title | Tumor Microenvironment PDF eBook |
Author | Constantinos Koumenis |
Publisher | Springer |
Pages | 300 |
Release | 2016-06-20 |
Genre | Medical |
ISBN | 3319266667 |
This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.
The Heterogeneity of Cancer Metabolism
Title | The Heterogeneity of Cancer Metabolism PDF eBook |
Author | Anne Le |
Publisher | Springer |
Pages | 186 |
Release | 2018-06-26 |
Genre | Medical |
ISBN | 331977736X |
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions
Title | Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions PDF eBook |
Author | Debabrata Banerjee |
Publisher | Springer Nature |
Pages | 171 |
Release | 2021-12-09 |
Genre | Medical |
ISBN | 3030832821 |
Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
Tumor Microenvironment
Title | Tumor Microenvironment PDF eBook |
Author | Dietmar W. Siemann |
Publisher | John Wiley & Sons |
Pages | 407 |
Release | 2011-06-24 |
Genre | Science |
ISBN | 1119956927 |
The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.
Autophagy in tumor and tumor microenvironment
Title | Autophagy in tumor and tumor microenvironment PDF eBook |
Author | Sujit Kumar Bhutia |
Publisher | Springer Nature |
Pages | 284 |
Release | 2020-10-24 |
Genre | Medical |
ISBN | 9811569304 |
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Tumor Microenvironment
Title | Tumor Microenvironment PDF eBook |
Author | Alexander Birbrair |
Publisher | Springer Nature |
Pages | 176 |
Release | 2020-02-06 |
Genre | Science |
ISBN | 3030355829 |
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.