Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.

A valuable guide to scoring crown and root traits in human dentitions for ancestry estimation and biodistance analysis.

Reprint of the original, first published in 1883.

This book describes and explains the basis of bio-inspired, leading-edge tubercles based on humpback whale flippers as passive but effective flow control devices, as well as providing a comprehensive practical guide in their applications. It first discusses the morphology of the humpback whale flipper from a biological perspective, before presenting detailed experimental and numerical findings from past investigations by various experts on the benefits of leading-edge tubercles and their engineering implementations. Leading-edge tubercle designs and functions have attracted considerable interest from researchers in terms of understanding their role in the underwater agility of these whales, and to exploit their flow dynamics in the development of new and novel engineering solutions. Extensive research over the past recent years has demonstrated that the maneuverability of these whales is at least in part due to the leading-edge tubercles acting as passive flow control devices to delay stall and increase lift in the post-stall regime. In addition to the inherent benefits in terms of aerodynamics and hydrodynamics, investigations into leading-edge tubercles have also broadened into areas of noise attenuation, stability and industrial applications. This book touches upon these areas, with an emphasis upon the effects of lifting-surface types, flow regimes, tubercle geometries, lifting-surface stability and potential industrial applications, among others. As such, it features contributions from key experts in the fields of biology, physics and engineering who have conducted significant studies into understanding the various aspects of leading-edge tubercles. Given the broad coverage and in-depth analysis, this book will benefit academic researchers, practicing engineers and graduate students interested in tapping into such a unique but highly functional flow control strategy.