Written by an international group of renowned experts, the Fifth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of all common and uncommon movement disorders. Coverage includes Parkinson's disease, other neurodegenerative diseases, tremors, dystonia, Tourette's syndrome, Huntington's disease, and ataxias. This edition features extensive updates on genetics, imaging, and therapeutics of Parkinson's disease, other parkinsonian disorders, and all hyperkinetic movement disorders. A bound-in CD-ROM, Video Atlas of Movement Disorders, demonstrates the movement and posture abnormalities and other disturbances associated with Parkinson's disease and other neurologic disorders.

'Essential Tremor' is a guide for sufferers to minimising the impact it has on their lives. It provides first-hand advice on the causes of, treatment options for, and methods of coping with this condition.

Anthony, Shamus, and Lefty Award Finalist Powerful forces on each side of the law have Rick Cahill in the crosshairs Nightmares of the man he killed two years ago still chase Rick Cahill through his sleep. The memory of his murdered wife haunts him during waking hours. His private investigative work, secretly photographing adulterers, paid for his new house but stains his soul. When an old nemesis asks for his help to free a man from prison, a man he thinks is wrongly convicted of murder, Rick grabs at the chance to turn his life around. His investigation takes him from the wealthy enclave of La Jolla to the dark underbelly of San Diego. His quest fractures his friendship with his mentor, endangers his steady job, and draws the contempt of the Police Chief who has tried to put Rick behind bars forever. With the police on one side of the law and a vicious biker gang on the other, all trying to stop him from freeing the man in prison, Rick risks his life to uncover the truth that only the real killer knows—what happened one bloody night eight years earlier. Perfect for fans of David Baldacci While all of the novels in the Rick Cahill PI Crime Series stand on their own and can be read in any order, the publication sequence is: Yesterday's Echo Night Tremors Dark Fissures Blood Truth Wrong Light Lost Tomorrows Blind Vigil Last Redemption (coming November 2021)

Since the Global Financial Crisis, the structure of financial markets has undergone a dramatic shift. Modern markets have been “zombified” by a combination of Central Bank policy, disintermediation of commercial banks through regulation, and the growth of passive products such as ETFs. Increasingly, risk builds up beneath the surface, through a combination of excessive leverage and crowded exposure to specific asset classes and strategies. In many cases, historical volatility understates prospective risk. This book provides a practical and wide ranging framework for dealing with the credit, positioning and liquidity risk that investors face in the modern age. The authors introduce concrete techniques for adjusting traditional risk measures such as volatility during this era of unprecedented balance sheet expansion. When certain agents in the financial network behave differently or in larger scale than they have in the past, traditional portfolio theory breaks down. It can no longer account for toxic feedback effects within the network. Our feedback-based risk adjustments allow investors to size their positions sensibly in dangerous set ups, where volatility is not providing an accurate barometer of true risk. The authors have drawn from the fields of statistical physics and game theory to simplify and quantify the impact of very large agents on the distribution of forward returns, and to offer techniques for dealing with situations where markets are structurally risky yet realized volatility is low. The concepts discussed here should be of practical interest to portfolio managers, asset allocators, and risk professionals, as well as of academic interest to scholars and theorists.

The Bard meets "House" in this illumination of the medical mysteries surrounding 10 of the English language's most heralded writers, including John Milton, Jonathan Swift, and Jack London.