This unique book bridges the gap between toxicology and chemistry at a level understandable by a wide spectrum of readers with various interests and a broad range of backgrounds in chemistry, biochemistry, and toxicology. The third edition has been thoroughly updated and expanded to reflect recent advances in important areas of research, including toxicogenetics and toxic effects on various body systems. Toxicological Chemistry and Biochemistry, Third Edition begins by outlining the basic concepts of general chemistry, organic chemistry, and biochemistry needed to understand the topics in the book. The author then presents an overview of environmental chemistry so that you can understand the remainder of the material covered within that framework. He also discusses biodegradation, bioaccumulation, and biochemical processes that occur in water and soil. The new chapter on toxic effects considers toxicities to the endocrine and reproductive systems, and the section on xenobiotics analysis deals with the determination of toxicants and their metabolites in blood and other biological materials. The chapter on the genetic aspects of toxicology discusses the ways in which chemical damage to DNA can cause mutations, cancer, and other toxic effects on specific body systems, and it considers the role of genetics in determining individual susceptibilities to various toxicants. Toxicological Chemistry and Biochemistry, Third Edition retains the basic information and structure that made the first two editions popular with students and industry professionals, while enhancing the usefulness of the book and modernizing it in important areas. Review questions and supplementary references at the end of each chapter round out the third edition of this bestselling work.

Toxicological Chemistry, 2nd Edition provides an easy-to-understand general discussion of biological processes operating on environmental chemical species. It also focuses on the chemistry of toxic substances based on their interactions with biological tissue and living organisms. The book is designed to appeal to readers with diverse general backgrounds. It assumes only a minimal background in chemistry and none in biology or microbiology. Introductory material regarding these fields is presented in the first few chapters so that more sophisticated topics can be addressed throughout the remainder of the book. Detailed discussions about specific areas of research are avoided, although key references on major topics are provided for readers who require more in-depth information. Toxicological Chemistry, 2nd Edition is useful for anyone concerned with the biological fate and effects of chemicals. It is ideal as a general reference book, source of background material, or textbook for regulatory personnel, students, engineers with consulting firms, health and safety personnel, and others.

Written by a leader in the field, the Fundamentals of Environmental Chemistry, Second Edition puts the fundamentals of chemistry and environmental chemistry right at your students fingertips. Manahan presents the material in an understandable and interesting manner without being overly simplistic. They get basic coverage on: - Matter and the basis of its physical nature and behavior - Organic and biological chemistry - Chemistry of water, soil, and air - Industrial chemistry - Toxicological chemistry as it pertains to occupational health and human exposure to pollutants and toxicants - Energy, nuclear energy, and nuclear waste - Applications of nuclear science in areas such as tracing pesticide degradation and nuclear medicine - More than an introduction to this field, Fundamentals of Environmental Chemistry, Second Edition provides the foundation that gives your students an understanding of the chemical processes of the environment and the effects pollution on those processes.

Fundamentals of Environmental and Toxicological Chemistry: Sustainable Science, Fourth Edition covers university-level environmental chemistry, with toxicological chemistry integrated throughout the book. This new edition of a bestseller provides an updated text with an increased emphasis on sustainability and green chemistry. It is organized based on the five spheres of Earth’s environment: (1) the hydrosphere (water), (2) the atmosphere (air), (3) the geosphere (solid Earth), (4) the biosphere (life), and (5) the anthrosphere (the part of the environment made and used by humans). The first chapter defines environmental chemistry and each of the five environmental spheres. The second chapter presents the basics of toxicological chemistry and its relationship to environmental chemistry. Subsequent chapters are grouped by sphere, beginning with the hydrosphere and its environmental chemistry, water pollution, sustainability, and water as nature’s most renewable resource. Chapters then describe the atmosphere, its structure and importance for protecting life on Earth, air pollutants, and the sustainability of atmospheric quality. The author explains the nature of the geosphere and discusses soil for growing food as well as geosphere sustainability. He also describes the biosphere and its sustainability. The final sphere described is the anthrosphere. The text explains human influence on the environment, including climate, pollution in and by the anthrosphere, and means of sustaining this sphere. It also discusses renewable, nonpolluting energy and introduces workplace monitoring. For readers needing additional basic chemistry background, the book includes two chapters on general chemistry and organic chemistry. This updated edition includes three new chapters, new examples and figures, and many new homework problems.

Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Although they are two aspects of the same subject, environmental toxicology and environmental chemistry are usually presented as though they are entirely separate from one another; even their practitioners often seem unaware of the connections. Environmental Toxicology and Chemistry is the first text to tie these subjects closely together, demonstrating the immediate relevance of each subject to the other while also providing basic, easily understandable introductions to both areas. This unique work presents their principles and applications through numerous illustrative examples and special topics that highlight current environmental concerns. It provides up-to-date as well as historical examples of both subjects and includes discussions of ecotoxicology, epidemiology, predictive methods, and other topics not covered in similar texts. It also includes invertebrates and nonmammal vertebrates, plants, and microorganisms, as well as humans and other mammals. The first five chapters place chemicals in the environment; the following five provide the biological and toxicological settings; and the remaining six chapters offer examples of specific chemicals, their toxic effects and significance, and predictions of fate and toxicity. Each chapter concludes with a discussion of a related topic of particular public and scientific interest, such as chemical carcinogens, pesticide residues, or hazardous wastes. Ideal for advanced undergraduate and graduate students in environmental toxicology courses, Environmental Toxicology and Chemistry offers a timely, comprehensive introduction to the principles of toxicology as they apply to our environment. It is also useful for professionals and practitioners in a wide range of environmentally related fields and businesses.

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.