Edelman links genetics, development, behavior, and evolution.

If you had a complete copy of a dinosaur's DNA and the genetic code, you still would not be able to make a dinosaur—or even determine what one looked like. Why? How do animals get their shape and how does shape evolve? In this important book, Nobel laureate Gerald M. Edelman challenges the notion that an understanding of the genetic code and of cell differentiation is sufficient to answer these questions. Rather, he argues, a trio of related issues must also be investigated—the development of form, the evolution of form, and the morphological and functional bases of behavior. Topobiology presents an introduction to molecular embryology and describes a comprehensive hypothesis to account for the evolution and development of animal form.

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.* Includes over 25 color tables* Topics covered include stem cells, zygotes, hepatocyte cell cycle, and mammary gland functions in seals* Six chapters edited by the most authoritative figures in their fields of study

One of the nation's leading neuroscientists presents a radically new view of the function of the brain and the nervous system. Its central idea is that the nervous system in each individual operates as a selective system resembling natural selection in evolution, but operating by different mechanisms. This far-ranging theory of brain functions is bound to stimulate renewed discussion of such philosophical issues as the mind-body problem, the origins of knowledge and the perceptual bases of language. Notes and Index.

Written by Nobel Prize laureate Gerald M. Edelman, this book develops a remarkable theory of consciousness that integrates findings from the recent explosive growth of the neurosciences with current knowledge of anatomy, cell biology, and psychology. In constructing a detailed model of how we become aware of our own existence, Edelman provides an outlook that may prompt a fundamental revision in the way linguists view language, physicians classify mental disease, and philosophers look at the mind-body problem. Notes and Index.

In this bold, provocative account, the author argues that the phenomena of life and mind elude purely materialistic explanations. Living matter occupies a unique phase of existence which results from the complex transformation of its biochemical synergies. Analogous phase changes account for mind and self-reflexive consciousness. A central role in the living state is played by intelligence, which has not been recognised as a non-negotiable precondition of organic existence. Yet the concept of evolutionary adaptivity relies tacitly on it. Thus the book amounts to a serious challenge to the overly theoretical paradigmata of the last half-century with their timorous evasion of biological fundamentals. However, although the work relies on up-to-date research of the life sciences, it is a primarily philosophical enquiry, dealing head on with many unsolved problems of life and mind, and culminating in a detailed “ontological proof” of the mind system.

Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies.