This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Whereas most crops drive farmers apart as they compete for the best prices, the price controls on tobacco bring growers together. The result is a culture unlike any other in America, one often forgotten or overlooked as federal and state governments fight over the spoils of the tobacco settlement. Tobacco Culture describes the process of raising a crop of burley from the perspective and experience of the farmers themselves. In the process of gathering information for the book, the authors performed most steps in the tobacco production process, from dropping plants, burning seedbeds, topping, and cutting to stripping and baling the finished product. Van Willigen and Eastwood document both present practices and historical developments in tobacco farming at the very moment a way of life stands poised for dramatic change. In addition to growing practices, the authors found other common threads linking growers and tobacco producing regions. Where tobacco is grown, it often becomes the major cash crop and carries the health of the economy. Farmer Oscar Richardson states, "It's bread and butter. It's the industry of the community, the state as a whole.... You take tobacco out of Kentucky and this farmland wouldn't be worth a nickel." Combining cultural anthropology and oral history, John van Willigen and Susan Eastwood have created a remarkable portrait of the heart of the burley belt in Central Kentucky.

The bulk of the world’s tobacco is produced in low- and middle-income countries. In order to dissuade these countries from implementing policies aimed at curbing tobacco consumption (such as increased taxes, health warnings, advertising bans and smoke-free environments), the tobacco industry claims that tobacco farmers will be negatively affected and that no viable, sustainable alternatives exist. This book, based on original research from three continents, exposes the myths behind these claims.

Burley tobacco revolutionized the industry in east Tennessee and western North Carolina. What started from two farmers planting white burley in Greeneville ignited an agricultural revolution and significantly changed crops, production and quality. By the 1990s, burley tobacco production int he region had drastically declined, and it is a tradition that few local farmers still practice.