Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

This biography of James Edmund Reeves, whose legislative accomplishments cemented American physicians' control of the medical marketplace, illuminates landmarks of American health care: the troubled introduction of clinical epidemiology and development of botanic medicine and homeopathy, the Civil War's stimulation of sanitary science and hospital medicine, the rise of government involvement, the revolution in laboratory medicine, and the explosive growth of phony cures. It recounts the human side of medicine as well, including the management of untreatable diseases and the complex politics of medical practice and professional organizing. Reeves' life provides a reminder that while politics, economics, and science drive the societal trajectory of modern health care, moral decisions often determine its path.