During the early 1900s, in examining the workings of the nervous system, physiologists were beginning to explore the idea that the transmission of nerve impulses takes place, in part, through or by chemical means. Otto Loewi decided to explore this idea. During a stay in London in 1903, he met Sir Henry Dale, who was also interested in the chemical transmission of nerve impulses. However, for Otto Loewi, Dale, and all the other researchers pursuing a chemical transmitter of nerve impulses, years of effort produced no solid evidence. In 1921 Loewi suspended two frogs' hearts in solution, one with a major nerve removed. Removing fluid from the heart that still contained the nerve, and injecting the fluid into the nerveless heart, Loewi observed that the second heart behaved as if the missing nerve were present. The nerves, he concluded, do not act directly on the heart - it is the action of chemicals, freed by the stimulation of nerves, that causes increases in heart rate and other functional changes. In 1926 Loewi and his colleagues identified one of the chemicals in his experiment as ‘acetylcholine’. This was indisputably a neurotransmitter - a chemical that serves to transmit nerve impulses in the involuntary nervous system.

New York Times bestseller One of the top ten books of the year at The New York Times Book Review, The Wall Street Journal, Vulture/New York magazine A best book of the year at Los Angeles Times, Time, NPR, The Washington Post, Bookforum, The New Yorker, Vogue, Kirkus The acclaimed, award-winning New Yorker writer Rachel Aviv offers a groundbreaking exploration of mental illness and the mind, and illuminates the startling connections between diagnosis and identity. Strangers to Ourselves poses fundamental questions about how we understand ourselves in periods of crisis and distress. Drawing on deep, original reporting as well as unpublished journals and memoirs, Rachel Aviv writes about people who have come up against the limits of psychiatric explanations for who they are. She follows an Indian woman celebrated as a saint who lives in healing temples in Kerala; an incarcerated mother vying for her children’s forgiveness after recovering from psychosis; a man who devotes his life to seeking revenge upon his psychoanalysts; and an affluent young woman who, after a decade of defining herself through her diagnosis, decides to go off her meds because she doesn’t know who she is without them. Animated by a profound sense of empathy, Aviv’s gripping exploration is refracted through her own account of living in a hospital ward at the age of six and meeting a fellow patient with whom her life runs parallel—until it no longer does. Aviv asks how the stories we tell about mental disorders shape their course in our lives—and our identities, too. Challenging the way we understand and talk about illness, her account is a testament to the porousness and resilience of the mind.

An original novel based on the thrilling Star Trek movies directed by J.J. Abrams! Taking place in an alternate timeline created when the Starship Kelvin was destroyed by a Romulan invader from the future, this bold new novel follows Captain James T. Kirk and an inexperienced crew commandeering a repaired U.S.S. Enterprise out of spacedock for a simple shakedown cruise. When a distress call comes in, the Enterprise must aid a large colony ship of alien refugees known as the Perenorean, who are under siege by an unknown enemy. But Kirk and his crew will find that the situation with the peaceful Perenorean is far more complicated than they bargained for, and the answers as to why they were attacked in the first place unfold in the most insidious of ways…

Hailed by Andre Gide as the patron saint of all outsiders, Simone Weil's short life was ample testimony to her beliefs. In 1942 she fled France along with her family, going firstly to America. She then moved back to London in order to work with de Gaulle. Published posthumously The Need for Roots was a direct result of this collaboration. Its purpose was to help rebuild France after the war. In this, her most famous book, Weil reflects on the importance of religious and political social structures in the life of the individual. She wrote that one of the basic obligations we have as human beings is to not let another suffer from hunger. Equally as important, however, is our duty towards our community: we may have declared various human rights, but we have overlooked the obligations and this has left us self-righteous and rootless. She could easily have been issuing a direct warning to us today, the citizens of Century 21.

Among the most profound questions we confront are the nature of what and who we are as conscious beings, and how the human mind relates to the rest of what we consider reality. For millennia, philosophers, scientists, and religious thinkers have attempted answers, perhaps none more meaningful today than those offered by neuroscience and by Buddhism. The encounter between these two worldviews has spurred ongoing conversations about what science and Buddhism can teach each other about mind and reality. In Mind Beyond Brain, the neuroscientist David E. Presti, with the assistance of other distinguished researchers, explores how evidence for anomalous phenomena—such as near-death experiences, apparent memories of past lives, apparitions, experiences associated with death, and other so-called psi or paranormal phenomena, including telepathy, clairvoyance, and precognition—can influence the Buddhism-science conversation. Presti describes the extensive but frequently unacknowledged history of scientific investigation into these phenomena, demonstrating its relevance to questions about consciousness and reality. The new perspectives opened up, if we are willing to take evidence of such often off-limits topics seriously, offer significant challenges to dominant explanatory paradigms and raise the prospect that we may be poised for truly revolutionary developments in the scientific investigation of mind. Mind Beyond Brain represents the next level in the science and Buddhism dialogue.

"Christopher White's Unsettled Minds makes clear how important new psychologies of religion were for those Protestants navigating their way out of Calvinism and evangelical revivalism. Just as his religious liberals remapped mind and spirit, White has remapped the historical terrain of religion and psychology in American culture. He spotlights not a cultural world absorbed with ecstasy, altered states, or mythic depths, but instead one riveted on measured stages of spiritual growth and effective habits of self-discipline."—Leigh Eric Schmidt, Princeton University "An important contribution to the growing literature on the history of religious experience and of the distinctive dynamics of Christian interiority in the modern U.S."—Robert Orsi, Northwestern University "Today, when brain researchers and psychologists are again attempting to explain religion, this remarkable study suggests that we should not be surprised to see religious believers creatively embracing new scientific findings and making use of them for religious purposes unexpected by scientists."—Ann Taves, author of Fits, Trances, and Visions

Shifts the narrative around the history of US higher education to examine its colonial past. Over the past several decades, higher education in the United States has been shaped by marketization and privatization. Efforts to critique these developments often rely on a contrast between a bleak present and a romanticized past. In Unsettling the University, Sharon Stein offers a different entry point—one informed by decolonial theories and practices—for addressing these issues. Stein describes the colonial violence underlying three of the most celebrated moments in US higher education history: the founding of the original colonial colleges, the creation of land-grant colleges and universities, and the post–World War II "Golden Age." Reconsidering these historical moments through a decolonial lens, Stein reveals how the central promises of higher education—the promises of continuous progress, a benevolent public good, and social mobility—are fundamentally based on racialized exploitation, expropriation, and ecological destruction. Unsettling the University invites readers to confront universities' historical and ongoing complicity in colonial violence; to reckon with how the past has shaped contemporary challenges at institutions of higher education; and to accept responsibility for redressing harm and repairing relationships in order to reimagine a future for higher education rooted in social and ecological accountability.