The Ultrastructure of Human Tumours: Applications in Diagnosis and Research describes the core features as seen by transmission electron microscopy, defining the different types of cellular differentiation in tumours; this is relevant for tumour nomenclature and diagnosis, which, in turn, are important for tumour pathologists in their collaboration with oncologists for the treatment of cancer patients. The book is divided into 8 chapters. Following an introduction on technique and procedure, there are chapters on epithelial tumours, melanocytic lesions, soft-tissue and related tumours, lymphoma and leukaemia, CNS neoplasms and neuroendocrine and neuronal tumours. Each chapter includes an introductory text that puts the ultrastructural features in the context of classical pathology. The book includes many new findings and interpretations from well-known tumours, as well as ultrastructural information on several newly described tumour entities not dealt with in existing tumour ultrastructure monographs. The book will especially be of value to tumour pathologists who need to solve problem cases with the aid of electron microscopy, but also to cancer research and tissue engineering scientists working to develop anti-cancer and stem-cell-based therapies. However, even those without access to electron microscopy may also benefit from this book, since many of the images provide an ‘explanation’ of the appearances of cells, tissues and tumours familiar to pathologists and scientists from light microscopy. In this respect, it is hoped that this book will stimulate the wider use of electron microscopy in pathology. The book is comprehensively referenced, 680 pages long and lavishly illustrated with 757 figures. Dr. Brian Eyden is Consultant Clinical Scientist and Dr. S. Sankar Banerjee Consultant Histopathologist in the Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK; Dr. Yongxin Ru is Director of the Department of Electron Microscopy, Institute of Hematology and Blood Diseases Hospital, Tianjin, China; Paweł Liberski is Professor in the Department of Molecular Pathology and Neuropathology, Medical University Łódź, Poland.

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Diagnostic Electron Microscopy of Tumors, Second Edition is a guide on how to employ electron microscopy techniques in making evaluation on tumor biopsies. This edition aims to serve as a source of information, references, and electron micrographs for the practicing electron microscopists. This book is divided into five parts; each of which tackles a different topic. Part 1 discusses the collection of specimen, and Part 2 talks about the assessment of tumors' behavior and growth. Ultrastructural analysis of diagnostic problems is covered in Part 3; the significance of some ultrastructural features in tumors is explained in Parts 4 and 5. This text is recommended for those who wish to examine tumor biopsies with an electron microscope as well as those who want to become more conversant with such matters, so that they can understand and evaluate electron micrographs and reports. This book will be valuable to physicians, surgeons, histopathologists, and pathology residents.

Only with the advent of computed tomography and magnetic resonance imaging have radiologists become familiar with this uncommon pathology. The emphasis here is on MRI, as it guarantees the most accurate diagnosis of soft tissue tumours. Because of their rarity, multi-centric studies are necessary to collect statistically relevant numbers of these tumours and so assess the value of new imaging techniques in their detection, staging, grading, tissue characterisation, and post-treatment follow-up. This is a reflection of the work of a prestigious European study group of more than 30 such co-investigators - including experts on medical imaging - who collected more than 800 documented and histologically proven cases of soft tissue tumours. For each tumour type, 10-12 cases are shown, supported by 3-4 photos. Unsurpassed in its collection of case studies.