The new thrilling sci-fi novel from the author of New Pompeii and Empire of Time In a future London, humans are watched over by AIs and served by bots. But now that justice and jobs are meted out by algorithm, inequality blooms, and protest is brutally silenced. Anna Glover may be the most hated woman in the troubled city - the media's scapegoat for an unpopular war. Now she hides from the public eye, investigating neglected cases by using the mind-invading technology of the synapse sequencer to enter witnesses' memories. When a PI brings her a new high-stakes case, Anna sees a chance for atonement. But soon she is drawn into a plot that threatens to upend her hard-won anonymity and put everyone in danger - even those she hopes to save.

Sequential behavior is essential to intelligence in general and a fundamental part of human activities, ranging from reasoning to language, and from everyday skills to complex problem solving. Sequence learning is an important component of learning in many tasks and application fields: planning, reasoning, robotics natural language processing, speech recognition, adaptive control, time series prediction, financial engineering, DNA sequencing, and so on. This book presents coherently integrated chapters by leading authorities and assesses the state of the art in sequence learning by introducing essential models and algorithms and by examining a variety of applications. The book offers topical sections on sequence clustering and learning with Markov models, sequence prediction and recognition with neural networks, sequence discovery with symbolic methods, sequential decision making, biologically inspired sequence learning models.

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a conceptual structure that would allow the synapse to be identified at the beginning of the 20th century. Numerous illustrations explain either the technical approach or the experimental finding.

The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. A comprehensive reference focused on the structure and function of the synapse Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

Physiology is a comprehensive presentation of core physiologic concepts with a focus on mechanisms. Renowned physiology instructor Linda S. Costanzo covers important concepts in the field, both at the organ system and cellular levels. Easy to read and user-friendly, the revised fourth edition stresses essential and relevant content with absolute clarity and includes concise step-by-step explanations complemented by numerous tables and abundant illustrations. It provides information on the underlying principles of cellular physiology, the autonomic nervous system, and neurophysiology, as well as the cardiovascular, respiratory, renal, acid-base, gastrointestinal, endocrine, and reproductive organ systems. This book is ideal as both a textbook and as a review guide for the boards. Provides step-by-step explanations and easy-to-follow diagrams clearly depicting physiologic principles. Integrates equations and sample problems throughout the text. Presents chapter summaries for quick overviews of important points. Contains boxed Clinical Physiology Cases to provide you with more clinical examples and a more thorough understanding of application. Provides questions at the end of each chapter for an extensive review of the material and to reinforce your understanding and retention. Offers a full-color design and all full-color illustrations throughout. Features increased coverage of pathophysiology in the neurophysiology, gastrointestinal, renal, acid-base, and endocrine chapters to emphasize this important component of the USMLE exam. Incorporates further practice in solving physiology equations through the inclusion of additional problem-solving questions throughout the text.

For fifteen years, the Romans of New Pompeii have kept the outside world at bay with the threat of using the Novus Particles device to alter time. Yet Decimus Horatius Pullus—once Nick Houghton—knows the real reason the Romans don’t use the device for their own ends: they can’t make it work without grisly consequences. This fragile peace is threatened when an outsider promises to help the Romans use the technology. And there are those beyond Pompeii’s walls who are desperate to destroy a town where slavery flourishes. When his own name is found on an ancient artifact dug up at the real Pompeii, Nick knows that someone in the future has control of the device. The question is: whose side are they on?