Alberto Rios explains the world not through reason but magic. These poems-set in a town that straddles Mexico and Arizona-are lyric adventures, crossing two and three boundaries as easily as one, between cultures, between languages, between senses. Drawing upon fable, parable, and family legend, Rios utilizes the intense and supple imagination of childhood to find and preserve history beyond facts: plastic lemons turning into baseballs, a grandmother's long hair reaching up to save her life, the painted faith jumpers leaping to the earth and crowd below. This is magical realism at its shimmering best. The smallest muscle in the human body is in the ear. It is also the only muscle that does not have blood vessels; It has fluid instead. The reason for this is clear: The ear is so sensitive that the body, if it heard its own pulse, Would be devastated by the amplification of its own sound. In this knowledge I sense a great metaphor, But I do not want to be hasty in trying to capture or describe it. Words are our weakest hold on the world. -from "Some Extensions of the Sovereignty of Science" "Rios is onto something new in his poetry-in the way that the real poets of any time always are."-American Book Review Alberto Rios teaches at Arizona State and is the author of eight books of poetry, three collections of short stories, and a memoir about growing up on the Mexican border. He is the recipient of numerous awards and his work is included in over 175 national and international literary anthologies. His work is regularly taught and translated, and has been adapted to dance and both classical and popular music.

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The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References

Classically, manipulations of the cranium address the sutures, the membranes and the circulation of cerebral spinal fluid. The proper functioning of these elements requires not only the mechanical harmony of the craniosacral system, but relies also on the exchange of information organized around proprioceptors, baroreceptors and chemoreceptors. These receptors are extremely sensitive. It is the nervous system -cranial nerves and the autonomic nervous system - which transports this intelligence. Neural dysfunctions have, therefore the ability to disturb the fundamental components of the primary respiratory mechanism. Entirely new, original and abundantly illustrated, this book is an essential guide with which to visualize and become familiar with the cranial nerves. It will teach the practitioner manipulations of this delicate neural system as well as new techniques which permit one to have an effect on the most precious part of the cranium: the brain.

An understanding of the structure and function of the human body is vital for anyone studying the medical and health sciences. In this book, Leslie Klenerman provides a clear and accessible overview of the main systems of the human anatomy, illustrated with a number of clear explanatory diagrams.

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.