The Sliding-Filament Theory of Muscle Contraction

The Sliding-Filament Theory of Muscle Contraction
Title The Sliding-Filament Theory of Muscle Contraction PDF eBook
Author David Aitchison Smith
Publisher Springer
Pages 433
Release 2019-02-05
Genre Medical
ISBN 3030035263

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Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.

Anatomy and Physiology

Anatomy and Physiology
Title Anatomy and Physiology PDF eBook
Author J. Gordon Betts
Publisher
Pages 0
Release 2013-04-25
Genre
ISBN 9781947172807

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Anatomy & Physiology

Anatomy & Physiology
Title Anatomy & Physiology PDF eBook
Author Lindsay Biga
Publisher
Pages
Release 2019-09-26
Genre
ISBN 9781955101158

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A version of the OpenStax text

Basic Physiology for Anaesthetists

Basic Physiology for Anaesthetists
Title Basic Physiology for Anaesthetists PDF eBook
Author David Chambers
Publisher Cambridge University Press
Pages 469
Release 2019-07-25
Genre Medical
ISBN 1108463991

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Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.

Muscle Biophysics

Muscle Biophysics
Title Muscle Biophysics PDF eBook
Author Rassier Dilson J.E
Publisher Springer Science & Business Media
Pages 360
Release 2010-09-08
Genre Science
ISBN 1441963669

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Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.

Mechanism of Muscular Contraction

Mechanism of Muscular Contraction
Title Mechanism of Muscular Contraction PDF eBook
Author Jack A. Rall
Publisher Springer
Pages 480
Release 2014-10-21
Genre Medical
ISBN 1493920073

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This book describes the evolution of ideas relating to the mechanism of muscular contraction since the discovery of sliding filaments in 1954. An amazing variety of experimental techniques have been employed to investigate the mechanism of muscular contraction and relaxation. Some background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. Controversies in the muscle field are discussed along with some missed opportunities and false trails. The pathway to ATP and the high energy phosphate bond will be discussed, as well as the discovery of myosin, contraction coupling and the emergence of cell and molecular biology in the muscle field. Numerous figures from original papers are also included for readers to see the data that led to important conclusions. This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.

Skeletal Muscle Mechanics

Skeletal Muscle Mechanics
Title Skeletal Muscle Mechanics PDF eBook
Author W. Herzog
Publisher John Wiley & Sons
Pages 586
Release 2000-10-03
Genre Science
ISBN 9780471492382

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Dieses Teilgebiet der Biomechanik ist für Sportwissenschaftler und Physiologen von großer Bedeutung! Die umfassende, aktuelle Abhandlung der Skelettmuskelmechanik beschäftigt sich mit drei Themenkreisen: den Mechanismen der Skelettmuskelkontraktion, der Muskelfunktion in vivo und theoretischen Modellen der Muskelfunktion. Auch ein knapper historischer Abriß und ein Ausblick auf noch offene Fragen fehlen nicht. (08/00)