Karen Harper’s crowd-pleasing Elizabeth I Mystery series, hailed as “extraordinary” by the Los Angeles Times, continues with this marvelous, majestic novel. The Queene’s Cure transports us into the shadowy world of sixteenth-century medicine, as an enlightened young queen seeks the cures that could heal a realm and transform a land.... In late summer of 1562, within a bedchamber at Whitehall Palace, Elizabeth Tudor prays for the recovery of the delirious, fever-racked friend who has served her for twenty-six of her twenty-nine years. Ten days later, with loyal, handsome Lord Robert Dudley by her side, the queen leads her retinue to London’s Royal College of Physicians to enlist two learned doctors in the raging battle against disease and pestilence. She knows she has no trusted allies in Peter Pascal and John Caius, ardent Papist sympathizers with long-standing grievances against the Tudors. Yet even the stalwart queen is shaken when a frighteningly lifelike effigy of herself ravaged by pox turns up in her royal coach. Elizabeth’s fear that the counterfeit corpse is a harbinger of impending tragedy comes to fruition when ever more terrifying transgressions penetrate the very heart of her royal precincts. With the help of her Privy Plot Council and an intriguing healer whose curative arts are at odds with the dangerous Royal College, Elizabeth resolves to unmask a murderer who wears a false face and is beset by the vilest humours of the soul. But when she herself falls ill, an entire realm is caught in the grip of a treasonous conspiracy to take a queen’s life and throne. Peopled by a rich cast of fascinating figures from the swirling mists of history, The Queene’s Cure brings a vibrant, violent age unforgettably to life. Racing to a chilling climax where ordinary men play God and where Elizabeth Tudor could meet the same fate as her mother, Anne Boleyn, this is a gripping and captivating story of an indomitable young monarch...fighting for her life, her realm, and her rightful crown.

Cure Models: Methods, Applications and Implementation is the first book in the last 25 years that provides a comprehensive and systematic introduction to the basics of modern cure models, including estimation, inference, and software. This book is useful for statistical researchers and graduate students, and practitioners in other disciplines to have a thorough review of modern cure model methodology and to seek appropriate cure models in applications. The prerequisites of this book include some basic knowledge of statistical modeling, survival models, and R and SAS for data analysis. The book features real-world examples from clinical trials and population-based studies and a detailed introduction to R packages, SAS macros, and WinBUGS programs to fit some cure models. The main topics covered include the foundation of statistical estimation and inference of cure models for independent and right-censored survival data, cure modeling for multivariate, recurrent-event, and competing-risks survival data, and joint modeling with longitudinal data, statistical testing for the existence and difference of cure rates and sufficient follow-up, new developments in Bayesian cure models, applications of cure models in public health research and clinical trials.