National Geographic's riveting narrative explores the world of placebos, hypnosis, false memories, and neurology to reveal the groundbreaking science of our suggestible minds. Could the secrets to personal health lie within our own brains? Journalist Erik Vance explores the surprising ways our expectations and beliefs influence our bodily responses to pain, disease, and everyday events. Drawing on centuries of research and interviews with leading experts in the field, Vance takes us on a fascinating adventure from Harvard's research labs to a witch doctor's office in Catemaco, Mexico, to an alternative medicine school near Beijing (often called "China's Hogwarts"). Vance's firsthand dispatches will change the way you think--and feel. Expectations, beliefs, and self-deception can actively change our bodies and minds. Vance builds a case for our "internal pharmacy"--the very real chemical reactions our brains produce when we think we are experiencing pain or healing, actual or perceived. Supporting this idea is centuries of placebo research in a range of forms, from sugar pills to shock waves; studies of alternative medicine techniques heralded and condemned in different parts of the world (think crystals and chakras); and most recently, major advances in brain mapping technology. Thanks to this technology, we're learning how we might leverage our suggestibility (or lack thereof) for personalized medicine, and Vance brings us to the front lines of such study.

Placebo responses are automatic and unconscious and cannot be predicted on conscious volition. Instead, they reflect complex interactions between the innate reward system of the nervous system and encoded procedural memories and imaginal fantasies. This book contributes therapeutic effects, varies in potency, and exhibits its own pathologies.

The biological power of the placebo effect. The power of placebos to ameliorate symptoms has been with us for centuries. Western medicine today is finding it increasingly difficult to ignore the efficacy of placebos. In some clinical trials with placebos as controls, inert or sham replicas of active pharmaceutical drugs and even sham surgeries have been found to be as beneficial as the intervention being tested. In this volume in the MIT Press Essential Knowledge series, Kathryn Hall examines the power of placebos, showing how their effects can influence our clinical trials, clinical encounters and, collectively, Hall argues, our public health. Hall, who has studied the placebo effect for years, reviews the history of the placebo in medicine, tracing its evolution from quackery and patent medicine to its use as a control in clinical trials. She considers the ways that expectations and learning affect our response to placebos; advances in neuroimaging that reveal the inner workings of the placebo effect; the “nocebo” effect; placebo controls in randomized clinical trials; and the use of psychological profiles and genetics to predict individual placebo response. The effects of placebos have been hiding in plain sight; with this book, Hall helps bring them into clearer view.

The Placebo Effect in Clinical Practice brings together what we know about the mechanisms behind the placebo response, as well as the procedures that promote these responses, in order to provide a focused and concise overview on how current knowledge can be applied in treatment settings.

This is the first book to critically review the mechanisms of placebo effects across all medical conditions, diseases and therapies. It is the definitive text on the placebo effect, and will be essential for researchers and clinicians in all medical specialties.

Beginning with a review of the role of placebos in the history of medicine, this book investigates the current surge of interest in placebos, and probes the methodological difficulties of saying scientifically just what placebos can and cannot do.