This handbook is a compilation of major clinical trials in all subspecialties in the field of ophthalmology. Each trial is presented in a uniform manner, detailing the background and purpose of the study, design, number of subjects with inclusion and exclusion criteria, outcomes, then results and conclusions. Topics include glaucoma, cornea, diabetic retinopathy, age-related macular degeneration, retinal detachment, neuro-ophthalmology, ocular melanoma, and many more. Trials are arranged chronologically or in order of significance, with extensive referencing for further reading. ‘At a glance’ tables summarising each trial are also included. The previous edition of this comprehensive text (9789350907740) published in 2013.

The field of ophthalmology has advanced considerably in the past several decades in terms of surgical and technical advancements, understanding the mechanism of diseases and treating conditions that were once considered untreatable. As is the case with so many other specialties in medicine, ophthalmology is guided by "evidence based medicine," based on the results of randomised controlled trials (RCTs). To put this powerful information in the hands of clinicians, this handbook was developed to provide a succinct yet comprehensive review of the most essential evidence-based medicine in ophthalmology. This essential text forms a framework for the evidence-based clinical practice of ophthalmic technicians, residents, academic and private practitioners of ophthalmology as well as researchers, optometrists and others. It also serves as a core review text for tests such as the OKAP and ophthalmology board exams, which emphasise knowledge based in the outcomes of major RCTs. This text covers the major research carried out in all of the subspecialties of ophthalmology including cornea, medical and surgical retina, glaucoma, oculoplastics, neuro-ophthalmology, and pediatric ophthalmology. Each chapter has been carefully edited by top academic faculty at the Duke University Eye Center, who have an intimate understanding of the essential knowledge contained within the current ophthalmic literature and have contributed commentary on the results. This book therefore is not only a convenient review of the vital knowledge in ophthalmology, but also provides a keen analysis by world experts of the most up-to-date research in their respective fields. In short, this book promises to change the way eye care professionals use RCTs in clinical practice by putting this powerful information conveniently in their hands.

The field of ophthalmology has advanced considerably in the past several decades in terms of surgical and technical advancements, understanding the mechanism of diseases and treating conditions that were once considered untreatable. As is the case with so many other specialties in medicine, ophthalmology is guided by "evidence based medicine," based on the results of randomized controlled trials (RCTs). To put this powerful information in the hands of clinicians, this handbook was developed to provide a succinct yet comprehensive review of the most essential evidence-based medicine in ophthalmology. This essential text forms a framework for the evidence-based clinical practice of ophthalmic technicians, residents, academic and private practitioners of ophthalmology as well as researchers, optometrists and others. It also serves as a core review text for tests such as the OKAP and ophthalmology board exams, which emphasize knowledge based in the outcomes of major RCTs. This text covers the major research carried out in all of the subspecialties of ophthalmology including cornea, medical and surgical retina, glaucoma, oculoplastics, neuro-ophthalmology, and pediatric ophthalmology. Each chapter has been carefully edited by top academic faculty at the Duke University Eye Center, who have an intimate understanding of the essential knowledge contained within the current ophthalmic literature and have contributed commentary on the results. This book therefore is not only a convenient review of the vital knowledge in ophthalmology, but also provides a keen analysis by world experts of the most up-to-date research in their respective fields. In short, this book promises to change the way eye care professionals use RCTs in clinical practice by putting this powerful information conveniently in their hands.

Pivotal Trials in Ophthalmology: A Guide for Trainees is an introductory text designed to give trainees a comprehensive and accessible overview of landmark trials in the different subspecialties of ophthalmology, and may also serve as a useful reference for practicing ophthalmologists, optometrists and researchers in the field. The text is subdivided by subspecialty, with each chapter authored by both a trainee and an expert in the field. A selection of pivotal research studies that have shaped how practitioners diagnose, manage, and treat disease are reviewed in chronological order. The purpose, study design, results, and study limitations are reviewed, and the key takeaway points from each study are listed in a digestible, bullet-point format. By listing the studies in chronological order, the reader will have an understanding of how studies have built upon each other and how knowledge has evolved over time. This text can serve as a basic introductory text for first year ophthalmology residents around which a standardized curriculum can be shaped, a study guide for board examination study, or a reference text for practitioners and researchers at any stage of training and practice.

This handbook offers a systematic summary of ophthalmic disease directed towards diagnosis, interim assessment and ongoing management. Now including an extensive online image bank the fourth edition provides rapid access to the information when it is needed, whether in the clinic, theatre or on the ward

Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every key aspect of preparing and conducting clinical trials, including: Interdisciplinary topics that have to be coordinated for a successful clinical trialData management (and adverse event reporting systems) Biostatistics, pharmacology, and toxicology Modeling and simulation Regulatory monitoring and ethics Particular issues for given disease areas-cardiology, oncology, cognitive, dementia, dermatology, neuroscience, and more With unique information on such current issues as adverse event reporting (AER) systems, adaptive trial designs, and crossover trial designs, Clinical Trials Handbook will be a ready reference for pharmaceutical scientists, statisticians, researchers, and the many other professionals involved in drug development.