The Nude Mouse in Experimental and Clinical Research presents the state of knowledge regarding the nude mouse and its applications to different branches of scientific research. The research studies featured in this book emphasize the academic status of a broad range of subjects and techniques of nude mouse research. The text consists of 21 chapters, each discussing an important aspect of nude mouse research. Some chapters discuss the biological aspect such as physiology, genes, and breeding and mass production of the mouse. A number of the chapters also discuss the general observations of the mouse like histopathological observations and their background. The applications of the nude mouse to human tumor and cancer cell research are likewise given emphasis. This book will be of valuable importance to both students and researchers in the fields of medicine, biology, and pathology.

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of transplantation sites and transplantability of human tumor tissue to the animals includes both the description of host factors and the tumor type involved. The characterization and monitoring of xenografts is followed by a review on their possible application for studies in tumor biology, such as hormones, growth factors, drug resistance, tumor markers, and heterogeneity. Experimental therapy is dedicated to cytostatic agents, hormones, monoclonal antibodies, cytokines, differentiation inducers and radiotherapy. The book also provides critical remarks regarding the limitation of the nude-mouse tumor models. The Nude Mouse in Oncology Research will provide essential reference information for oncology researchers, researchers who work with the nude mouse on a regular basis, and pharmaceutical companies.

This informative guide provides a comprehensive overview of the biology and care of immunodeficient rodents, which are essential for the study of human diseases and the development of new treatments. It is an invaluable resource for scientists, veterinarians, and animal care professionals. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.