Pappagallo (neurology, Albert Einstein College of Medicine; chronic pain, Beth Israel Medical Center) compiles the latest work from international contributors on the scientific basis of pain medicine, issues related to the pain physician, pain syndromes and disorders, and therapies. Some topics examined include opioid pharmacology, brain imaging of

This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.

Painâ€"it is the most common complaint presented to physicians. Yet pain is subjectiveâ€"it cannot be measured directly and is difficult to validate. Evaluating claims based on pain poses major problems for the Social Security Administration (SSA) and other disability insurers. This volume covers the epidemiology and physiology of pain; psychosocial contributions to pain and illness behavior; promising ways of assessing and measuring chronic pain and dysfunction; clinical aspects of prevention, diagnosis, treatment, and rehabilitation; and how the SSA's benefit structure and administrative procedures may affect pain complaints.

This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

"Social pain is the experience of pain as a result of interpersonal rejection or loss, such as rejection from a social group, bullying, or the loss of a loved one. Research now shows that social pain results from the activation of certain components in physical pain systems. Although social, clinical, health, and developmental psychologists have each explored aspects of social pain, recent work from the neurosciences provides a coherent, unifying framework for integrative research. This edited volume provides the first comprehensive, multidisciplinary exploration of social pain. Part I examines the subject from a neuroscience perspective, outlining the evolutionary basis of social pain and tracing the genetic, neurological, and physiological underpinnings of the phenomenon. Part II explores the implications of social pain for functioning in interpersonal relationships; contributions examine the influence of painkillers on social emotions, the ability to relive past social hurts, and the relation of social pain to experiences of intimacy. Part III examines social pain from a biopsychosocial perspective in its consideration of the health implications of social pain, outlining the role of stress in social pain and the potential long-term health consequences of bullying. The book concludes with an integrative review of these diverse perspectives"--Publicity materials. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.