The Molecular and Cellular Basis of Neurodegenerative Diseases
Title | The Molecular and Cellular Basis of Neurodegenerative Diseases PDF eBook |
Author | Michael S. Wolfe |
Publisher | Academic Press |
Pages | 561 |
Release | 2018-03-29 |
Genre | Medical |
ISBN | 0128113057 |
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts
The Molecular and Cellular Basis of Human Neurodegenerative Disease
Title | The Molecular and Cellular Basis of Human Neurodegenerative Disease PDF eBook |
Author | |
Publisher | |
Pages | |
Release | 1995 |
Genre | |
ISBN |
Molecular Mechanisms of Neurodegenerative Diseases
Title | Molecular Mechanisms of Neurodegenerative Diseases PDF eBook |
Author | Marie-Francoise Chesselet |
Publisher | |
Pages | 428 |
Release | 2014-01-15 |
Genre | |
ISBN | 9781468496024 |
The Molecular and Cellular Basis for Parkinson's Disease
Title | The Molecular and Cellular Basis for Parkinson's Disease PDF eBook |
Author | Thomas Müller |
Publisher | MDPI |
Pages | 230 |
Release | 2019-10-14 |
Genre | Science |
ISBN | 3039215485 |
The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research.
Molecular and Cellular Therapies for Motor Neuron Diseases
Title | Molecular and Cellular Therapies for Motor Neuron Diseases PDF eBook |
Author | Nicholas M Boulis |
Publisher | Academic Press |
Pages | 337 |
Release | 2017-01-18 |
Genre | Psychology |
ISBN | 0128025247 |
Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. - Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases - Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance - Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy
Neurodegenerative Diseases
Title | Neurodegenerative Diseases PDF eBook |
Author | Gary Fiskum |
Publisher | Springer Science & Business Media |
Pages | 469 |
Release | 2013-11-11 |
Genre | Science |
ISBN | 1489902090 |
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Neurodegeneration
Title | Neurodegeneration PDF eBook |
Author | Dennis Dickson |
Publisher | John Wiley & Sons |
Pages | 497 |
Release | 2011-09-09 |
Genre | Medical |
ISBN | 1444341235 |
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.