The Pulmonary Neuroepithelial Body Microenvironment
Title | The Pulmonary Neuroepithelial Body Microenvironment PDF eBook |
Author | Inge Brouns |
Publisher | Springer Nature |
Pages | 112 |
Release | 2021-05-05 |
Genre | Medical |
ISBN | 3030658171 |
This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors
The Pulmonary Neuroepithelial Body Microenvironment
Title | The Pulmonary Neuroepithelial Body Microenvironment PDF eBook |
Author | Inge Brouns |
Publisher | |
Pages | 0 |
Release | 2021 |
Genre | |
ISBN | 9783030658182 |
This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.
The Microenvironment of Pulmonary Neuroepithelial Bodies
Title | The Microenvironment of Pulmonary Neuroepithelial Bodies PDF eBook |
Author | Line Verckist |
Publisher | |
Pages | 272 |
Release | 2018 |
Genre | |
ISBN |
Functional Exploration of the Neuroepithelial Body Microenvironment in an Ex Vivo Lung Model
Title | Functional Exploration of the Neuroepithelial Body Microenvironment in an Ex Vivo Lung Model PDF eBook |
Author | Ian de Proost |
Publisher | |
Pages | 288 |
Release | 2008 |
Genre | |
ISBN |
The Neuroepithelial Body Microenvironment
Title | The Neuroepithelial Body Microenvironment PDF eBook |
Author | Robrecht Lembrechts |
Publisher | |
Pages | 231 |
Release | 2012 |
Genre | |
ISBN |
Pulmonary Neuroepithelial Bodies as Airway Oxygen Chemoreceptors
Title | Pulmonary Neuroepithelial Bodies as Airway Oxygen Chemoreceptors PDF eBook |
Author | |
Publisher | |
Pages | |
Release | 2000 |
Genre | |
ISBN |
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
Title | Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease PDF eBook |
Author | Venkataramana K Sidhaye |
Publisher | Academic Press |
Pages | 277 |
Release | 2017-03-09 |
Genre | Medical |
ISBN | 0128038810 |
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences