A unique, rigorous scientific approach to understanding bacterial genetics • Provides a complete overview of the entire field of bacterial genetics, helping the reader to understand how the field has evolved. • Inspires readers by providing an opportunity to learn from John Roth’s achievements and contributions to bacterial genetics. • Offers valuable lessons in the history and science of bacterial genetics by providing a behind the scenes look at some of the most important triumphs and mishaps that have occurred on the path to discovery.

The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.

The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics

This book is based on an in-depth filmed conversation between Howard Burton and Jay Gargus, Professor of Physiology, Biophysics and Pediatrics and Director of the Center for Autism Research and Translation at UC Irvine. This wide-ranging conversation examines the recent explosion in our genetic understanding and its implications for the future of medicine, together with the importance of understanding the underlying molecular mechanisms in order to successfully treat a wide range of genetic disorders. Prof. Gargus focuses on autism, dispelling myths associated with the condition, advocating why a treatment should be actively pursued, and illustrating what we can learn from the recent breakthrough in cystic fibrosis research. This carefully-edited book includes an introduction, Machine Repair, and questions for discussion at the end of each chapter: I. The Lure of Genetics - Where the action was—and still is II. Genetics 101 - A basic overview III. Towards Disease - Intervening in metabolic pathways IV. Autism - Myths, current understanding and challenges V. Pathways and Pleiotropy - Searching for mechanisms VI. Reasons for Optimism - Streamlined bureaucracy and bold prognostications About Ideas Roadshow Conversations: This book is part of an expanding series of 100+ Ideas Roadshow conversations, each one presenting a wealth of candid insights from a leading expert through a focused yet informal setting to give non-specialists a uniquely accessible window into frontline research and scholarship that wouldn't otherwise be encountered through standard lectures and textbooks.

Viruses infect numerous microorganisms including, predominantly, Bacteria (bacteriophages or phages) but also Archaea, Protists, and Fungi. They are the most abundant and ubiquitous biological entities on Earth and are important drivers of ecosystem functioning. Little is known, however, about the vast majority of these viruses of microorganisms, or VoMs. Modern techniques such as metagenomics have enabled the discovery and description of more presumptive VoMs than ever before, but also have exposed gaps in our understanding of VoM ecology. Exploring the ecology of these viruses – which is how they interact with host organisms, the abiotic environment, larger organisms, and even other viruses across a variety of environments and conditions – is the next frontier. Integration of a growing molecular understanding of VoMs with ecological studies will expand our knowledge of ecosystem dynamics. Ecology can be studied at multiple levels including individual organisms, populations, communities, whole ecosystems, and the entire biosphere. Ecology additionally can consider normal, equilibrium conditions or instead perturbations. Perturbations are of particular interest because measuring the effect of disturbances on VoM-associated communities provides important windows into how VoMs contribute to ecosystem dynamics. These disturbances in turn can be studied through in vitro, in vivo, and in situ experimentation, measuring responses by VoM-associated communities to changes in nutrient availability, stress, physical disruption, seasonality, etc., and could apply to studies at all ecological levels. These are considered here across diverse systems and environments.

Particularly in the humanities and social sciences, festschrifts are a popular forum for discussion. The IJBF provides quick and easy general access to these important resources for scholars and students. The festschrifts are located in state and regional libraries and their bibliographic details are recorded. Since 1983, more than 659,000 articles from more than 30,500 festschrifts, published between 1977 and 2011, have been catalogued.

Conversations About Biology include the following five carefully-edited Ideas Roadshow Conversations featuring leading researchers with a detailed preface highlighting the connections between the different books: I. Autism: A Genetic Perspective - A conversation with Jay Gargus, Professor of Physiology, Biophysics and Pediatrics and Director of the Center for Autism Research and Translation at UC Irvine. This wide-ranging conversation examines the recent explosion in our genetic understanding of autism and its implications for the future of medicine, together with the importance of understanding the underlying molecular mechanisms in order to successfully treat a wide range of genetic disorders. Jay Gargus focuses on autism, dispelling myths associated with the condition, advocating why a treatment should be actively pursued, and illustrating what we can learn from the recent breakthrough in cystic fibrosis research. II. Learning and Memory - A conversation with Alcino Silva, Distinguished Professor of Neurobiology, Psychiatry and Psychology at the David Geffen School of Medicine and Director of the Integrated Center for Learning and Memory at UCLA. This book is based on an in-depth filmed conversation between Howard Burton and Alcino Silva who runs a learning and memory lab at UCLA that is focused on a vast number of topics, from schizophrenia and autism to learning and memory. This fascinating conversation explores how he and his colleagues focus on understanding the specific molecular mechanisms of neurobiology with the goal of being able to intervene and repair these mechanisms when they go awry. III. A Matter of Energy: Biology From First Principles - A conversation with Nick Lane, Professor of Evolutionary Biochemistry at University College London. This book is based on an in-depth filmed conversation between Howard Burton and Nick Lane.. After an inspiring story of Nick Lane’s career path, this wide-ranging conversation covers his bioenergetic view of early, evolutionary history, the origin of life and how all complex life is composed of a very particular cell type that we all share, and more. IV. Our Human Variability - A conversation with Stephen Scherer, the GlaxoSmithKline Research Chair in Genome Sciences at the Hospital for Sick Children and University of Toronto. This book is based on an in-depth filmed conversation between Howard Burton and Stephen Scherer who discusses his lifelong passion for science that culminated in his groundbreaking discovery of copy-number variation. This conversation also covers his exciting work in autism research and how copy number variation brings us a deeper understanding of both human variability and disease. V. Sleep Insights - A conversation with Matthew Walker, Professor of Neuroscience and Psychology and Founder and Director of the Center for Human Sleep Science at UC Berkeley. This book is based on an in-depth filmed conversation between Howard Burton and Matthew Walker. This extensive conversation gives a clear and compelling picture of our recent understanding of sleep's essential role in our daily lives, from reinforcing learning and memory to regulating emotion. Howard Burton is the creator and host of Ideas Roadshow and was the Founding Executive Director of Perimeter Institute for Theoretical Physics.