Henry Snyder III was born ca. 1777 in Lancaster Co., Pennsylvania. He was a descendant of Jacob Snyder (or Schneider) who immigrated to America ca. 1739 and settled in Pennsylvania. Henry married Catharine Keplinger sometime prior to the year 1805. They lived in Boonsboro, Maryland and were the parents of seven known children. Descendants lived in Maryland, Ohio, Indiana, Kansas, Michigan, Missouri, Texas, Canada and elsewhere.

Descendants lived in Maryland, Virginia, West Virginia, Pennsylvania, California, and elsewhere in the United States. Allied families were Schneider (Snyder), Coffenbarger, Osbourn, Miller, Link, Lowe, Hendricks, Hammond, Engle, and many others.