Given the success of the previous edition of this Research Topic, we are pleased to announce the release of its second volume. Age-related changes can concurrently affect cognitive, motor, and sensory functioning and their interactions. For instance, age-related unisensory impairments have been linked to slower gait, functional mobility decline, increased risks of falls and reduced quality of life. Additionally, balance impairments have been associated with inefficient interactions between musculoskeletal and sensory systems which are often compromised in aging. Lastly, inefficient multisensory integration processes have been linked to increased falls, worse balance, slower gait, and increased cognitive impairments. Consequently, the successful interaction among sensory, motor and cognitive systems are an integral aspect for everyday life activities, which commonly deteriorate with age.

Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.

For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.

As our society ages, the topic of cognitive aging is becoming increasingly important. This volume provides an accessible overview of how the cognitive system changes as a function of normal aging. Building on the successful first edition, this volume provide an even more comprehensive coverage of the major issues affecting memory, attention, language, speech and other aspects of cognitive functioning. The essential chapters from the first edition have been thoroughly revised and updated and new chapters have been introduced which draw in neuroscience studies and more applied topics. In addition, contributors were encouraged to ensure their chapters are accessible to students studying the topic for the first time. This therefore makes the volume appealing as a textbook on senior undergraduate and graduate courses.

Despite impressive advances in understanding sleep as a biological phenomenon and in understanding the nature of mental processes in the normal waking state, our knowledge of mental life during sleep remains extremely impoverished. The common identification of cognition with consciousness leaves the impression that little or no mental activity occurs during sleep. The present volume represents the Proceedings of the Arizona Conference on Sleep and Cognition, held in Tucson January 19-22, 1989. A principal concern of the conference was the implications of recent work on implicit memory and other aspects of information-processing outside of awareness for studies of cognitive processes during sleep, and the role of the sleep laboratory as a vehicle for studying various aspects of information processing outside of awareness, in the absence of the active deployment of attention. To this end, selected investigators in the area of sleep who have an interest in cognitive processes were brought together with their counterparts in the area of cognition who have an interest in sleep. We hope that one outcome of this meeting, and publication of the Proceedings, will be a new agenda for research on sleep that will carry investigators of both camps well into the 21st century.

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.