Tom Waller knows danger. As a highly trained agent for Tailfeather, the Nation’s most secret security organization, he has faced numerous perils throughout his service. This time, however, a seemingly innocent favor for Esme Barrows, his fiancé, may be his most explosive mission. Anton Kaszor, one of the world’s most brilliant and richest men and both a client and former lover of Esme, needs this favor. A favor which exposes Tom to unanticipated consequences. Meanwhile, John W. Bingham, senior senator from the State of Delaware and popular chairmen of the United States Senate Arms Committee is about to announce his presidential candidacy for the Republican Party at a national event. Suddenly, the senator mysteriously disappears from the campaign hall and Anton, his closest friend and biggest collaborator, may be involved. Tom gets drawn into the vortex of Anton’s psychological maelstrom as the past envelops the present and threatens the lives of everyone important to him.

The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics. Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics. The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations. Examples throughout highlight the application of imaging genetics to understand neurochemical systems and pathways, explore relationships between genetics and the structural and functional connectivity in human brain, and provide insight into mechanisms of risk for psychiatric and neurologic illness.

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

The complete reference of biological bases for psychopathology at any age Developmental Psychopathology is a four-volume compendium of the most complete and current research on every aspect of the field. Volume Two: Developmental Neuroscience focuses on the biological basis of psychopathology at each life stage, from nutritional deficiencies to genetics to functional brain development to evolutionary perspectives and more. Now in its third edition, this comprehensive reference has been fully updated to better reflect the current state of the field, and detail the newest findings made possible by advances in technology and neuroscience. Contributions from expert researchers and clinicians provide insight into brain development, molecular genetics methods, neurogenics approaches to pathway mapping, structural neuroimaging, and much more, including targeted discussions of specific disorders. Advances in developmental psychopathology have burgeoned since the 2006 publication of the second edition, and keeping up on the latest findings in multiple avenues of investigation can be burdensome to the busy professional. This series solves the problem by collecting the information into one place, with a logical organization designed for easy reference. Consider evolutionary perspectives in developmental psychopathology Explore typical and atypical brain development across the life span Examine the latest findings on stress, schizophrenia, anxiety, and more Learn how genetics are related to psychopathology at different life stages The complexity of a field as diverse as developmental psychopathology deepens with each emerging theory, especially with consideration of the rapid pace of neuroscience advancement and genetic discovery. Developmental Psychopathology Volume Two: Developmental Neuroscience provides an invaluable resource by compiling the latest information into a cohesive, broad-reaching reference.

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons, launch a new Series “Metal Ions in Life Sciences”. The philosophy of the Series is based on the one successfully applied to a previous series published by another publisher, but the move from “biological systems” to “life sciences” will open the aims and scope and allow for the publication of books touching on the interface between chemistry, biology, pharmacology, biochemistry and medicine. Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2,800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine. In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenensis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights in the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases...and it reveals the chaperones of nickel metabolism.

Many theorists now believe that development emerges out of the coming together of multiple influences on the developing organism. To understand development, not only is it important to identify these influences, but it is necessary to describe their relationship to one another. In this dynamic view of development, emergent organization is the result of the components of development coming together. Timing is concerned with the relationship between components that have different rates of development. This book brings together the work of several investigators who have contributed to our understanding of the impact of timing on development through the examination of different functions and different organisms. By juxtaposing their work it is possible to see that the concept of timing has explanatory value at various levels of organization for the understanding of development. The book's unifying theme allows the reader to make conceptual analogies across species and across levels of organization without being reductionistic. Presenting the work of researchers in developmental and experimental psychology, biopsychology, neuropsychology, life span development, and medicine, the book offers a theoretical base from which to examine the value of using timing as a construct and specific examples of research programs which have utilized timing to frame their research questions.

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. - Features a section on neurological and imaging, including SPECT Neuroimaging - Analyzes how diet and nutrition effect depression - Examines the molecular and cellular effects of depression - Covers genetics of depression - Includes more than 250 illustrations and tables