Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.

Stemming from environmental, genetic, and situational factors, chronic disease is a critical concern in modern medicine. Managing treatment and controlling symptoms is imperative to the longevity and quality of life of patients with such diseases. Chronic Illness and Long-Term Care: Breakthroughs in Research and Practice features current research on the diagnosis, monitoring, management, and treatment of chronic diseases such as diabetes, Parkinson's disease, autoimmune disorders, and many more. Highlighting a range of topics such as medication management, quality-of-life issues, and sustainable health, this publication is an ideal reference source for hospital administrators, healthcare professionals, academicians, researchers, and graduate-level students interested in the latest research on chronic diseases and long-term care.

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Seasoned clinicians comprehensively, yet succinctly, summarize their years of experience in the diagnosis and treatment of acute and chronic pain across a wide variety of medical conditions. Drawing on their extensive personal knowledge of internal medicine, family practice, rheumatology, neurology, cardiology, as well as of urology, oncology, neurology, physical medicine, and gastroenterology, they provide all the practical information needed by busy practitioners to initiate appropriate diagnostic tests and therapy-without having to consult other references. Treatment is presented in practical terms, with specific but full information given on medications and dosages.

Draws on the latest scientific findings to identify the unique characteristics, chemical makeups, and structural differences of migraine-prone brains, offering insight into the role of the central nervous system while outlining a comprehensive program to reduce the frequency and intensity of headaches. Reprint.