In Untying the Gordian Knot: Process, Reality, and Context, Timothy E. Eastman proposes a new creative synthesis, the Logoi framework—which is radically inclusive and incorporates both actuality and potentiality—to show how the fundamental notions of process, logic, and relations, woven with triads of input-output-context and quantum logical distinctions, can resolve a baker’s dozen of age-old philosophic problems. Further, Eastman leverages a century of advances in quantum physics and the Relational Realism interpretation pioneered by Michael Epperson and Elias Zafiris and augmented by the independent research of Ruth Kastner and Hans Primas to resolve long-standing issues in understanding quantum physics. Adding to this, Eastman makes use of advances in information and complex systems, semiotics, and process philosophy to show how multiple levels of context, combined with relations—including potential relations—both local and local-global, can provide a grounding for causation, emergence, and physical law. Finally, the Logoi framework goes beyond standard ways of knowing—that of context independence (science) and context focus (arts, humanities)—to demonstrate the inevitable role of ultimate context (meaning, spiritual dimension) as part of a transformative ecological vision, which is urgently needed in these times of human and environmental crises.