In the seventeenth century scientific discoveries called into question established Christian theology. It has been claimed that contemporary thinkers contributed to this conflict model by using the discoveries of the natural world to prove the existence of God. Calloway challenges this view by close examination of five key texts of the period.

Atheists generated widespread anxieties between the Reformation and the Enlightenment. In response to such anxieties a distinct genre of religious apologetics emerged in England between 1580 and 1720. By examining the form and the content of the confutation of atheism, Anti-Atheism in Early Modern England demonstrates the prevalence of patterned assumptions and arguments about who an atheist was and what an atheist was supposed to believe, outlines and analyzes the major arguments against atheists, and traces the important changes and challenges to this apologetic discourse in the early Enlightenment.