The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

The Exposome: A New Paradigm for the Environment and Health, Second Edition, is a thoroughly expanded and updated edition of The Exposome: A Primer, the first book dedicated to the topic. This new release outlines the purpose and scope of this emerging field of study, its practical applications, and how it complements a broad range of disciplines. The book contains sections on -omics-based technologies, newer detection methods, managing and integrating exposome data (including maps, models, computation and systems biology), and more. Both students and scientists in toxicology, environmental health, epidemiology and public health will benefit from this rigorous, yet readable, overview. This updated edition includes a more in-depth examination of the exposome, including full references, further reading and thought questions.

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

Environmental health is an area with significant developments and noteworthy challenges that expand into various disciplines: medicine and public health, sociology and communications, technology, policymaking, and legislation. Due to the massive amount of health-related issues, additional literature involving environmental health is required to improve the wellbeing of citizens worldwide. Environmental Exposures and Human Health Challenges provides interdisciplinary insights into concepts and theories related to environmental exposures and human health impacts via the air, water, soil, heavy metal exposure, and other chemical toxins. The book also addresses inequalities and environmental injustices in relation to environmental exposures and health impacts. Covering topics such as health policies, pollution effects, and heavy metal exposure, this publication is designed for public health professionals, preventive medicine specialists, clinicians, data scientists, environmentalists, academicians, practitioners, researchers, and students.

Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. - Presents recent advances in the field of breath analysis - Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design - Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments - Acts as both a primer for beginners and a reference for seasoned researchers

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.