Many U.S. government agencies rely on nonprofit federally funded research and development centers (FFRDCs) for independent expertise in systems engineering and integration, study and analysis, and research and development. In this report, the authors discuss insights drawn from academic literature and practitioner guidance that are applicable to the effective oversight, management, and performance assessment of FFRDCs. They identify (1) institutional prerequisites for enabling effective oversight, management, and performance assessment of FFRDCs and (2) operational criteria for running constructive assessment processes. Whereas academics and practitioners have written volumes on internal assessment-when an organization examines its own programs and employees-and commercial acquisitions, they have had comparatively little to say about relationships involving FFRDCs. However, research on performance management systems and related or subsidiary processes, including performance reviews and program evaluation, is broadly applicable to government oversight of and engagement with FFRDCs. Thus, the authors examine a wide range of literature and guidance on performance management and program evaluation, looking for best practices in other potentially analogous and relevant organizational contexts, modifying and supplementing the processes as needed to account for contextual differences and other needs.--