An urgent plea for a broader understanding and awareness of the unconsidered dangers of new genetic technologies Since 2010 it has been possible to determine a person’s genetic makeup in a matter of days at an accessible cost for many millions of people. Along with this technological breakthrough there has emerged a movement to use this information to help prospective parents “eliminate preventable genetic disease.” As the prospect of systematically excluding the appearance of unwanted mutations in our children comes within reach, David B. Goldstein examines the possible consequences from these types of choices. Engaging and accessible, this clarion call for responsible and informed stewardship of the human genome provides an overview of what we do and do not know about human genetics and looks at some of the complex, yet largely unexplored, issues we must be most careful about as we move into an era of increasing numbers of parents exercising direct control over the genomes of their children.

“Will the future confront us with human GMOs? Greely provocatively declares yes, and, while clearly explaining the science, spells out the ethical, political, and practical ramifications.”—Paul Berg, Nobel Laureate and recipient of the National Medal of Science Within twenty, maybe forty, years most people in developed countries will stop having sex for the purpose of reproduction. Instead, prospective parents will be told as much as they wish to know about the genetic makeup of dozens of embryos, and they will pick one or two for implantation, gestation, and birth. And it will be safe, lawful, and free. In this work of prophetic scholarship, Henry T. Greely explains the revolutionary biological technologies that make this future a seeming inevitability and sets out the deep ethical and legal challenges humanity faces as a result. “Readers looking for a more in-depth analysis of human genome modifications and reproductive technologies and their legal and ethical implications should strongly consider picking up Greely’s The End of Sex and the Future of Human Reproduction... [It has] the potential to empower readers to make informed decisions about the implementation of advancements in genetics technologies.” —Dov Greenbaum, Science “[Greely] provides an extraordinarily sophisticated analysis of the practical, political, legal, and ethical implications of the new world of human reproduction. His book is a model of highly informed, rigorous, thought-provoking speculation about an immensely important topic.” —Glenn C. Altschuler, Psychology Today

Sometime in the next few years, some scientist may reprogram a human egg or sperm cell, make a change in the genetic instructions carried by that cell, a change that will be passed on down into eternity. The scientific expertise exists to do this, as does the motivation: to erase the chance of inheriting a disease, to improve the intelligence or the stamina or the beauty of a child. On the brink of an era that may be defined by genetic engineering, McKibben asks: should this happen? He argues that genetic engineering and the technologies that lie beyond it will launch us free of our past, of our humanity, of meaning. We are sleepwalking towards a future that will take us far away from all we have known: ENOUGH is our wake-up call.

This 4th edition is thoroughly updated version of the 3rd edition with its intact simple to-the-point presentation of knowledge, which makes the book examination friendly. This edition will be useful not only to the undergraduates, but also to the postgraduates, immunologists and geneticists. A chapter on "Stem Cell Therapy" Inclusion of Summary at the end of each chapter The concept of personalized medicine under Pharmacogenetics Information updation in nearly all chapters A chapter on "Stem Cell Therapy" Inclusion of Summary at the end of each chapter The concept of personalized medicine under Pharmacogenetics Information updation in nearly all chapters

In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology’s progress from gene to genome in one hundred years, The Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene—word and object—as the core explanatory concept of heredity and development. She argues that we need a new vocabulary that includes concepts such as robustness, fidelity, and evolvability. But more than a new vocabulary, a new awareness is absolutely crucial: that understanding the components of a system (be they individual genes, proteins, or even molecules) may tell us little about the interactions among these components. With the Human Genome Project nearing its first and most publicized goal, biologists are coming to realize that they have reached not the end of biology but the beginning of a new era. Indeed, Keller predicts that in the new century we will witness another Cambrian era, this time in new forms of biological thought rather than in new forms of biological life.

This book is especially prepared for the students of B.Sc. and M.Sc. of different Indian Universities as per UGC Model Curriculum. Students, preparing for Medical Entrance Examination, IAS, IFS, and PCS etc. will also be benefited by this book. At the end of some chapters of Genetic Engineering may enlighten the target readers. Entirely new information on Quantitative Genetics and Immunogenetics may enthral the readers. MCQ's ans answers will also be helpful for the students to strngthen their self confidence. By the help of numerous figures, many tables, boxes and coloured photographs, this book has tried to serve a balanced account of Classical Genetics and Modern Molecular Genetics. • This book is for Graduate, P.G. students of Biophysics, Microbiology& Biological Sciences.

Human Genetics and Genomics, Third Edition, is the new rendition of the classic textbook Human Genetics: A Problem-Based Approach. Thoroughly updated and restructured, this brand new edition uses both a classic didactic approach to teach basic genetic concepts and a problem-based approach to demonstrate the clinical applications of genetics in medical practice. By combining both these approaches, Human Genetics and Genomics is suitable both as a textbook for genetics courses, and as a bridge into the clinical environment. The third edition features greater emphasis on cutting edge technologies and the latest genetic issues, and a vast array of new pedagogy, such as: Clinical snapshots covering major genetic disorders Ethical Implications boxes discussing related ethical issues Key summary points at the beginning of each chapter and Q&As at the end of each chapter for self-assessment Hot topics covering new and emerging areas in genetics Recommended reading for each chapter A companion website at www.blackwellpublishing.com/korfgenetics